NTRK1

(redirected from Neurotrophic tyrosine kinase receptor type 1)

NTRK1

A gene on chromosome 1q21-q22 that encodes neurotrophic tyrosine kinase receptor type 1 (TrkA) which, after neurotrophin binding, phosphorylates itself (autophosphorylates) and members of the MAPK pathway. TrkA potently binds nerve growth factor (NGF) and is involved in differentiation and survival of neurons and in control of gene expression of enzymes involved in neurotransmitter synthesis. It is involved in cell differentiation and may play a role in specifying sensory neuron subtypes.

Molecular pathology
NTRK1 mutations are associated with congenital insensitivity to pain with anhidrosis, self-mutilating behaviour, mental retardation and cancer.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
The last decade has uncovered knowledge on the molecular determinants of lung cancer, and the probing of the NSCLC kinome using next-generation sequencing techniques has identified numerous nonoverlapping driver genomic events (i.e., activating mutations or rearrangements) involving targetable kinases, including epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), v-Raf murine sarcoma viral oncogene homolog B1, V-erb-b2 erythroblastic leukemia viral oncogene homolog 2 (ERBB2), rearranged during transfection, c-ros oncogene 1, and neurotrophic tyrosine kinase receptor type 1, among others.

Full browser ?