These findings suggest that TEN also increased action potential-independent neurotransmitter release
from the presynaptic terminals of Schaffer collateral-CA1 synapses (Sun and Kapur 2012).
Cdk5/p35 also was indicated inhibits neurotransmitter release
through the phosphorylation of P/Q-type voltage-dependent Ca2+ channel and down-regulation of the channel activity (Tomizawa et al.
Subcellular localization suggested a possible role for synapsin III in the regulation of neurotransmitter release
and synaptogenesis (14,15).
Recently, 6-OH-BDE-47 (6-hydroxy-2,2',4,4' -tetrabromodiphenyl ether), a hydroxylated metabolite of BDE-47 (2,2',4,4' -tetrabromodiphenyl ether), was demonstrated to increase vesicular neurotransmitter release
When activated, these receptors inhibit neurotransmitter release
via mechanisms that involve inhibition of voltage-gated calcium channels whose function is necessary for proper release.
Since synapsin is a neuronal phosphorprotein involved in the regulation of neurotransmitter release
, the binding of anti-gliadin antibodies to synapsin may reveal clues about the potential pathogenic roles of the antibody and its association with extra-intestinal complications.
Stimulation of the hair bundle, as we have seen, causes membrane depolarization, neurotransmitter release
, and action potential discharges in auditory nerve fibers.
It's not yet known whether shifts in electrical activity similarly influence neurotransmitter release
throughout embryonic nervous systems or in adult neurons.
BDNF is one of the most potent factors that encourages nerve tissue survival and regulates neurotransmitter release
and nerve growth.
Axonal transport and neurotransmitter release
, for example, are now known to occur by mechanisms that are related to those of membrane trafficking and secretion used by all eukaryotic cells, and the neurofilaments whose unusual staining properties allowed neuroanatomists to trace axonal tracts are now recognized as part of a larger family of intermediate filaments found in many cell types.
Dr Doughman's doctoral work was on phospholipid-dependent neurotransmitter release
mechanisms in neuronal systems at the University of Wisconsin, Department of Biochemistry.
Scheller (Genentech, South San Francisco, California) and Sudhof (Stanford University School of Medicine) will receive the 2013 Albert Lasker Basic Medical Research Award for discoveries concerning rapid neurotransmitter release
, a process key to the way our brain cells communicate.