However, the researchers said there is a need for a rigorously designed, larger clinical trial for a continued investigation into the potentiality of neuroprotective
effects of polyphenols, which is abundant in pomegranate juice.
The publication entitled, "Effects of Varying Intranasal Treatment Regimens in ST266-Mediated Retinal Ganglion Cell Neuroprotection," details the preclinical study exploring the neuroprotective
effects of daily and twice daily intranasally delivered ST266 to evaluate different treatment regimens an EAE-induced experimental ON mouse model.
potential of erythropoietin and darbepoetin alfa in an experimental model of sciatic nerve injury.
Although the exact mechanism behind the neuroprotective
effects of Hsd remains unclear, it is likely to demonstrate both antioxidant and calcium blocking properties.
Recently, there was also significant evidence indicating that gastrodin elicited strong neuroprotective
effects against loss of retinal ganglion cells in an acute glaucoma rat via inhibiting phosphorylated p38 MAPK and the production of proinflammatory mediators in activated retinal microglia.
UCLA researchers proposed that molecular mechanisms behind each disability may differ, and that neuroprotective
treatments tailored for each disability may be more effective than nonspecific treatments aiming to reduce a composite of different disabilities.
Tea contains antioxidants and anti-inflammatory and neuroprotective
chemicals, which have been associated with a lowered risk of serious conditions, including heart disease, cancer and diabetes, the researchers said.
Previous studies conducted with neurotoxic agents have demonstrated the neuroprotective
effect of selenium on the central and peripheral nervous systems (8,13-16).
Until now, many researchers have attempted to find neuroprotective
actions of medical plants and their components and studied their mechanisms of ischemia-induced neuronal death, such as glutamate-induced excitotoxicity, oxidative stress by excessive production of reactive oxygen species (ROS), and glial activation-mediated inflammatory response.[sup],,,,
The current study was aimed to observe the neuroprotective
effect of metformin against PTZ-induced apoptotic neurodegeneration in human cortical neuronal cell culture.
G-CSF exerts neuroprotective
actions through the inhibition of apoptosis and inflammation, and the stimulation of neurogenesis.
At present, lots of studies focus on exploring antiinflammatory and neuroprotective
agents that may alleviate cerebral I/R injury.