NOS1

(redirected from Neuronal NOS)

NOS1

A gene on chromosome 12q14-qter that encodes neuronal nitric oxide synthase (nNOS), a widely expressed enzyme that produces nitric oxide (NO). A messenger molecule with diverse functions throughout the body, nNOS plays a role in a wide range of physiological and pathological processes, including neurotransmission, neurotoxicity, muscle contraction, sexual function, fluid homeostasis and atherosclerosis.
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Table 1: Different forms of NO synthase have been classified as follows (14) Name Genes Location Neuronal NOS NOS1 Nervous Tissue (nNOS or NOS1) Skeletal Muscle Type Ii Inducible NOS NOS2 Immune System (iNOS or NOS2) Cardiovascular System Endothelial NOS NOS3 Endothelium (eNOS or NOS3 or cNOS) Bacterial NOS multiple Various Gram(+) Species (bNOS) Name Function Neuronal NOS Cell communication (nNOS or NOS1) Inducible NOS Immune defense against (iNOS or NOS2) pathogens Endothelial NOS Vasodilation (eNOS or NOS3 or cNOS) Bacterial NOS Defense Against Oxidative (bNOS) Stress, Antibiotics, Immune Attack
05), inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS) mRNA expression (1.
sodium ions, while the endothelial NOS (eNOS) and neuronal NOS (nNOS) pathways are activated in the presence of calcium ions.
Neuronal NOS and endothelial NOS, constitutively expressed calcium/calmodulindependent isoforms, demonstrate that nitric oxide plays an important role in normal homeostasis.
Recent studies revealed that mutation of a conserved proximal tryptophan-409 that forms one of three hydrogen bonds to the heme-coordinated cysteine thiolate, to tyrosine or phenylalanine considerably increases the turnover number of neuronal NOS (nNOS).
17] Neuronal NOS (nNOS) is the isoform that is expressed in the myenteric plexus of the gastrointestinal tract.
Importantly, KD7040 exhibits greater than 200-fold selectivity over neuronal NOS and 2000-fold selectivity over endothelial NOS, making the compound a potentially more efficacious treatment for neuropathic pain manifest in diseases such as PHN, diabetic neuropathy, lower back pain and carpal tunnel syndrome.

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