NOS1

(redirected from Neuronal NOS)

NOS1

A gene on chromosome 12q14-qter that encodes neuronal nitric oxide synthase (nNOS), a widely expressed enzyme that produces nitric oxide (NO). A messenger molecule with diverse functions throughout the body, nNOS plays a role in a wide range of physiological and pathological processes, including neurotransmission, neurotoxicity, muscle contraction, sexual function, fluid homeostasis and atherosclerosis.
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In slices from the hippocampal and entorhinal cortex, the application of non-specific inhibitors of nitric oxide synthase (NOS) or a selective neuronal NOS prevented low [Mg.sup.++]-induced epileptic activity.
There are three types of NOS: neuronal NOS (nNOS), endothelial NOS (eNOS), and inducible NOS (iNOS).
Raviten, an injectable solution of S-ethylisothiouronium diethylphosphate, has been shown in preclinical and exploratory clinical trials to inhibit inducible nitric oxide synthase (NOS), endothelial NOS, and neuronal NOS, thereby controlling overproduction of nitric oxide; and to normalize low blood pressure in patients suffering from intradialytic hypotension, as well as other low blood pressure conditions.
major promastigotes were analyzed for growth inhibition by calcimycin (0.5 [micro]M) as described in "Promastigote Growth Inhibition Assay." The effect of blocking constitutive NOS on Leishmania viability was studied by simultaneously adding selective neuronal NOS inhibitors: 50 [micro]M N[4-[2-[[(3- chlorophenyl)methyl]amino]ethyl]phenyl]-2- thiophenecarboxamide (ARL-17477) dihydrochloride (cat.
Li et al., "The anti-cancer agent SU4312 unexpectedly protects against MPP+-induced neurotoxicity via selective and direct inhibition of neuronal NOS," British Journal of Pharmacology, vol.
(20) NO plays an important role in the pulmonary systemic and cerebral vasodilation and is produced in response to increased intracellular calcium by endothelial NOS in endothelial cells and by neuronal NOS in astrocyte and neurons.
Neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS) mRNA and protein levels were measured in each sample by using real-time polymerase chain reaction and Western blotting.
In the organism, NO originates from L-arginine in a process catalyzed by three distinct NO synthase (NOS) enzymes: neuronal NOS (nNOS), endothelial NOS (eNOS), and inducible NOS (iNOS).
Tsai, "Noncontact erection is enhanced by Ginkgo biloba treatment in rats: role of neuronal NOS in the paraventricular nucleus and sacral spinal cord," Psychopharmacology, vol.
Exposure to high glucose increased nitrated proteins (1.56 fold p<0.05), inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS) mRNA expression (1.55 fold and 2.2 fold respectively, p<0.05 both), phospho-p38 MAPK (1.32 fold, p<0.05) abundance and decreased Schwann cell growth (11[+ or -]2%, p<0.05).
Additionally, in cerebral ischemia, constitutive NOS activity from the endothelial and neuronal NOS isoforms can be increased due to activation of various glutamate receptors, resulting in increased intracellular calcium and cytotoxicity [19].
This reaction is catalyzed by one of the three isoforms of NOS; neuronal NOS (nNOS), endothelial NOS (eNOS) and inducible NOS (INOS).

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