NOS1

(redirected from Neuronal NOS)

NOS1

A gene on chromosome 12q14-qter that encodes neuronal nitric oxide synthase (nNOS), a widely expressed enzyme that produces nitric oxide (NO). A messenger molecule with diverse functions throughout the body, nNOS plays a role in a wide range of physiological and pathological processes, including neurotransmission, neurotoxicity, muscle contraction, sexual function, fluid homeostasis and atherosclerosis.
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20) NO plays an important role in the pulmonary systemic and cerebral vasodilation and is produced in response to increased intracellular calcium by endothelial NOS in endothelial cells and by neuronal NOS in astrocyte and neurons.
Expression levels of neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS) as well as p22phox (a transmembrane subunit of NADPH oxidase) were investigated by real-time quantitative polymerase chain reaction (RT-qPCR) using a CFX96 Real-Time PCR detection system (Bio-Rad, USA).
Neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS) mRNA and protein levels were measured in each sample by using real-time polymerase chain reaction and Western blotting.
05), inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS) mRNA expression (1.
This reaction is catalyzed by one of the three isoforms of NOS; neuronal NOS (nNOS), endothelial NOS (eNOS) and inducible NOS (INOS).
sodium ions, while the endothelial NOS (eNOS) and neuronal NOS (nNOS) pathways are activated in the presence of calcium ions.
Neuronal NOS and endothelial NOS, constitutively expressed calcium/calmodulindependent isoforms, demonstrate that nitric oxide plays an important role in normal homeostasis.
To learn more about the role of NO in metamorphosis, we isolated and cloned a complementary DNA (cDNA) encoding a portion of the Ilyanassa ortholog of the neuronal NOS (nNOS) gene.
Recent studies revealed that mutation of a conserved proximal tryptophan-409 that forms one of three hydrogen bonds to the heme-coordinated cysteine thiolate, to tyrosine or phenylalanine considerably increases the turnover number of neuronal NOS (nNOS).
17] Neuronal NOS (nNOS) is the isoform that is expressed in the myenteric plexus of the gastrointestinal tract.
Importantly, KD7040 exhibits greater than 200-fold selectivity over neuronal NOS and 2000-fold selectivity over endothelial NOS, making the compound a potentially more efficacious treatment for neuropathic pain manifest in diseases such as PHN, diabetic neuropathy, lower back pain and carpal tunnel syndrome.
Depending on the cell type, NO is produced in an enzymatic reaction catalyzed by one of the three isoforms of NO synthase (NOS): neuronal NOS, endothelial NOS, and inducible NOS (2).

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