TAC1

(redirected from Neurokinin 1)

TAC1

A gene on chromosome 7q21-q22 that encodes four different tachykinins—substance P, neurokinin A, neuropeptide K and neuropeptide gamma—which are thought to function as neurotransmitters, interacting with nerve receptors and smooth muscle cells, inducing behavioural responses and acting as vasodilators and secretagogues.
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has begun enrollment in a 170-subject Phase 2 trial evaluating serlopitant, a neurokinin 1 receptor antagonist, as a treatment for refractory chronic cough, the company said.
Aprepitant is a substance P antagonist (through blocking neurokinin 1 receptor) and can be effective for some patients when taken three times a week, but it is not indicated for itch, Dr.
Now working their way through the developmental pipeline are two promising novel classes of drugs designed to target the physiologic mechanisms underlying this common and challenging problem: neurokinin 1 (NK1) receptor antagonists and selective opioid receptor agonists, explained Dr.
Finally, part three presents three case studies: T-type calcium channel and glycine transporter type 1 inhibitors, bioisosteric replacements for the neurokinin 1 receptor, and neuronal nitric oxide synthase inhibitors.
Substance P induces vomiting and binds to neurokinin 1 (NK-1) receptors in the abdominal vagus, the nucleus tractus solitarius, and the area postrema.
For OIH, proposed mechanisms include a role for glutaminergic activation (also implicated in tolerance), altered opioid intracellular signalling involving G protein-coupled receptor switching, a role for substance P and neurokinin 1 (NK-I) receptors and spinal dynorphin and, finally, increasing evidence implicating Toll-like receptor (TLR) signalling and glial cells.
Inflammation-induced upregulation of neurokinin 1 receptors in rat glabrous skin.
In addition, researchers are evaluating the therapeutic potential of corticotrophin-releasing factor antagonists and neurokinin 1 antagonists, which may address the relationship between stress and alcohol consumption.
Evidence for the involvement of metabotropic glutamatergic, neurokinin 1 receptor pathways and protein kinase C in the antinociceptive effect of dipyrone in mice.
current neurokinin 1 receptor antagonists) offer promise for more specific and possibly more effective and long-lasting treatment efficacy.
Contribution of neurokinin 1 receptors in the cutaneous orofacial cutaneous pain.