Substance P, with its preferred neurokinin 1
(NK1) receptor, is highly expressed in the amygdala and nucleus accumbens.
Role of neurokinin 1
receptors in dextran sulfate-induced colitis: studies with gene-deleted mice and the selective receptor antagonist netupitant.
Role of substance P and the neurokinin 1
receptor in acute pancreatitis and pancreatitis-associated lung injury.
has begun enrollment in a 170-subject Phase 2 trial evaluating serlopitant, a neurokinin 1
receptor antagonist, as a treatment for refractory chronic cough, the company said.
Aprepitant is a substance P antagonist (through blocking neurokinin 1
receptor) and can be effective for some patients when taken three times a week, but it is not indicated for itch, Dr.
Now working their way through the developmental pipeline are two promising novel classes of drugs designed to target the physiologic mechanisms underlying this common and challenging problem: neurokinin 1
(NK1) receptor antagonists and selective opioid receptor agonists, explained Dr.
Pei et al., "Acute colitis induces neurokinin 1
receptor internalization in the rat lumbosacral spinal cord," PLoS ONE, vol.
Hornby, "Substance P in the dorsal motor nucleus of the vagus evokes gastric motor inhibition via neurokinin 1
receptor in rat," Journal of Pharmacology and Experimental Therapeutics, vol.
Finally, part three presents three case studies: T-type calcium channel and glycine transporter type 1 inhibitors, bioisosteric replacements for the neurokinin 1
receptor, and neuronal nitric oxide synthase inhibitors.
Another study in patients with psoriasis showed that in noninvolved hairy skin of the arms and on the back chronic stress is associated with an increased number of inflammatory cells expressing neurokinin 1
receptor, most of them being mast cells .
Claesson, "Blockage of the neurokinin 1
receptor and capsaicin-induced ablation of the enteric afferent nerves protect SCID mice against T-cell-induced chronic colitis," Inflammatory Bowel Diseases, vol.