The mutations severely affect the function of Neurokinin
In Chapter 10, the authors review the genetics of neurokinin
B and its receptor and their role in the regulation of human GnRH secretion in hypogonadotropic hypogonadism (HH).
In addition, researchers are evaluating the therapeutic potential of corticotrophin-releasing factor antagonists and neurokinin
1 antagonists, which may address the relationship between stress and alcohol consumption.
1 receptor antagonists) offer promise for more specific and possibly more effective and long-lasting treatment efficacy.
KEY WORDS: airway innervation, asthma, muscarinic agonists, neurokinin
receptor, neurotrophic factor.
It has been shown that neurokinin
B (NKB) neurons are involved in the preovulatory surge of LH and that most of NKB neurons in ARC co-localise with the estrogen receptor.
demonstrated in receptor binding assays with three neuropeptide receptors--bradykinin II expressed in Chinese hamster ovary cells, neurokinin
I expressed in astrocytoma cells, and calcitonin gene related peptide (Sampson, et al, 2000).
And for the markers of inflammation we measured tachykinins, substance P and neurokinin
Alterations of neurokinin
receptors and interstitial cells of Cajal during and after jejunal inflammation induced by Nippostrongylus brasiliensis in the rat.
Newer agents are currently being explored in phase II trials: cholecystokinin antagonists, (113) [alpha]2 adrenergic agonists (clonidine), (114) k-opioid agonists (fedotozine), (115-117) a SSRI (citalopram), (118) and neurokinin
Capsaicin--a natural alkaloid extracted from red chili peppers--appears to work by depleting the neurokinin
substance P from peripheral nerves.
The wide variety of drugs in development includes opioid receptor ligands, bradykinin antagonists, newer COX inhibitors, glutamate receptor antagonists, substance P and neurokinin
receptor antagonists, P2X2 neuron receptor antagonists and nitric oxide-based analgesics.