All of these conditions aid in the differential diagnosis of Proteus Syndrome, which can be challenging because Klippel-Trenaunay-Weber syndrome, Maffucci's syndrome, enchondromatosis, neurofibromatosis type I, Bannayan-Zonana syndrome, hemihyperplasia, and Madelung's disease can also cause overgrowth [24, 27].
Neurofibromatosis type I, also known as von Recklinghausen's disease, was first described in 1882 by Friedrich Daniel von Recklinghausen.
Neurofibromatosis type I is a disorder characterized by the presence of two or more of the following findings: six or more "cafe au lait" macules (> 5 mm in diameter in puberty and > 15 mm in postpuberty patients), two or more neurofibromas of any type or one plexiform, freckling in the axillary or inguinal regions, optic glioma, two or more "Lish" nodules, and a distinctive osseous lesion.
Manifestations of the tongue in neurofibromatosis type I. Oral Dis.