The neurofibromatosis type 2
gene is inactivated in schwannomas.
Kita et al., "Tongue schwannomas associated with neurofibromatosis type 2
," Oral and Maxillofacial Surgery Cases, vol.
Spinal cord tanycytic ependymoma associated with neurofibromatosis type 2
. J Clin Neurosci 2010;17:922-4.
Neurofibromatosis type 2
is the major genetic condition that predisposes to meningioma formation, which are often multiple.
The 27-year-old suffers from the condition neurofibromatosis type 2
Past medical history included seasonal allergies, gastritis, left deep vein thrombosis (DVT), and neurofibromatosis type 2
Once thought to be a variant of NF1, neurofibromatosis type 2
is now characterized as a separate disorder deriving from an abnormality on chromosome 22.
Neurofibromatosis type 1 affects 1 in 2500 to 4000 individuals and is related to an abnormality of chromosome 17.[7,8] It is further characterized by systemic, neurologic, cosmetic, and orthopedic manifestations.[4,6,9,10] Type 2 affects 1 in 50,000 individuals and results from a chromosome 22 abnormality.[11,12] The most prominent feature of neurofibromatosis type 2
is bilateral acoustic nerve tumors.
Background: The auditory brainstem implants (ABIs) have been used to treat deafness for patients with neurofibromatosis Type 2
and nontumor patients.
(1,2) Neurofibromas are usually multiple upon presentation and are usually part of two autosomal dominant disorders with variable penetrance: neurofibromatosis type 1 (NF1, von Recklinghausen's disease) and neurofibromatosis type 2
(NF2, central or bilateral acoustic neurofibromatosis).