neurofibrillary tangle


Also found in: Encyclopedia, Wikipedia.

neu·ro·fi·bril·la·ry tan·gle

intraneuronal accumulations of helical filaments that assume twisted contorted patterns; found in cells of the hippocampus and cerebral cortex in patients with Alzheimer disease.

neurofibrillary tangle

A characteristic histologic finding in the perikaryon of large cortical neurones of patients with Alzheimer’s disease, which consists of fibrilised protein derived from microtubule-associated protein tau. The number of NFTs loosely correlates with the severity of dementia.
 
DiffDx
Down’s syndrome, subacute sclerosing panencephalitis, lead encephalopathy, tuberous sclerosis, Hallervorden-Spatz disease, lipofuscinosis, post-encephalitic parkinsonism, and normal adults (confined to the hippocampus).

neurofibrillary tangle

Neuropathology A characteristic histologic finding in the perikaryon of large cortical neurons of Pts with Alzheimer's disease, the number of NFTs loosely correlates with the severity of dementia DiffDx Down's syndrome, subacute sclerosing panencephalitis, lead encephalopathy, tuberous sclerosis, Hallervorden-Spatz disease, lipofuscinosis, post-encephalitic parkinsonism, and normal adults–confined to the hippocampus. See Alzheimer's disease, Amyloid plaque, Granulovacuolar degeneration, Paired helical filaments, Senile plaques.

Neurofibrillary tangle

—Twisted masses of protein inside nerve cells that develop in the brains of people with AD.
Mentioned in: Alzheimer's Disease
References in periodicals archive ?
Thus, the integrated effect of PKC activation on the complete amyloidogenic and neurofibrillary tangle pathways is to inhibit and prevent the pathologic hallmarks of AD.
In 1907, the German physician found microscopic bits of debris -- now called plaques and neurofibrillary tangles -- cluttering brain tissue taken from a 51-year-old woman who had suffered from dementia.
Columbia University Medical Center (CUMC) researchers found that abnormal tau protein, a key feature of the neurofibrillary tangles seen in the brains of those with Alzheimer's, propagates along linked brain circuits, "jumping" from neuron to neuron.
has executed a binding term sheet with Chinese pharmaceutical group Sinotau for investigational imaging agent (MK-6240) being evaluated for use in Positron Emission Tomography scans to image neurofibrillary tangles in the brain, the company said.
gov/pubmed/9748670) neurofibrillary tangles and two kinds of protein clusters called plaques  6 have been discovered together in marine mammals.
for use of [F-18]MK-6240, an investigational imaging agent to be used in Positron Emission Tomography (PET) scans for assessing the status and progression of neurofibrillary tangles (NFTs) in the brain.
Pathology analysis of treated animals showed obvious gliosis and neurofibrillary tangles in the cerebral hippocampal area.
Aloysius Alzheimer found that erythropoiesis formed by [beta]-amyloid (A[beta]) deposition and the highly-phosphorylated Tau protein-induced neurofibrillary tangles were the brain pathological features of Alzheimer's disease (AD).
One of the markers of Alzheimer's disease is the presence of amyloid-beta plaques and neurofibrillary tangles in the brain.
The scientists found that study participants who consumed a healthy Mediterranean-style diet, exercised regularly, and maintained a normal body mass index (BMI) had lower brain levels of sticky beta-amyloid plaques and neurofibrillary tangles associated with the onset of AD.
Scientists found consuming extra-virgin olive oil reduces the formation of amyloid-beta plaques and neurofibrillary tangles in the brain - classic markers of Alzheimer's.
Up to 50 percent of patients with the amyloid plaques and neurofibrillary tangles of AD also have the lesions characteristic of cerebrovascular disease.