neuroendocrine tumour

neuroendocrine tumour

An endocrine tumour neoplasm with a characteristic morphology, often composed of sheets and clusters of round blue cells with granular chromatin and an attenuated rim of poorly demarcated cytoplasm.
 
Clinical findings
NETs present with vague, nonspecific symptoms, including abdominal pain, nausea, weight loss and, rarely, obstructive symptoms; only 10% present with a carcinoid syndrome due to high circulating neuroendocrine hormones, in particular serotonin (5-HT), which causes flushing, diarrhoea, asthma and tricuspid regurgitation.

Examples
Carcinoids, small cell carcinomas, medullary carcinoma of thyroid, Merkel cell tumour, cutaneous neuroendocrine tumours, pancreatic islet cell tumours, pheochromocytoma.

Neuroendocrine tumour
Low grade—Typical carcinoid.
Intermediate grade—Atypical carcinoid.
High grade—Large cell: neuroendocrine tumour; small cell: lung cancer.
References in periodicals archive ?
16 ( ANI ): Finally breaking his silence, Irrfan Khan revelaed that he is diagnosed with NeuroEndocrine Tumour.
Learning that I have been diagnosed with neuroendocrine tumour as of now has been admittedly difficult, but the love and strength of those around me and that I found within me has brought me to a place of hope.
Treatment of liver metastases from neuroendocrine tumours in relation to the extent of hepatic disease.
Neuroendocrine tumours are often difficult to diagnose, their symptoms often vague and non-specific.
e centre will ocially receive the award at the European Neuroendocrine Tumour Society's T annual meeting in Barcelona this month.
Upper Gastrointestinal Endoscopy biopsy was reported as Neuroendocrine tumour.
The over production of protein and hormones can create several symptoms throughout the body that are common in other illnesses, a characteristic that renders neuroendocrine tumour diagnosis a difficult feat.
Neuroendocrine tumours affect one in every 50,000 people.
We report a case of post-surgical pancreatitis presenting clinically as recurrent neuroendocrine tumour of the pancreas.
Neuroendocrine tumours are slow-developing and originate from neuroendocrine cells; which are responsible for the production of hormones throughout the body.
Usually, neuroendocrine tumors involving the spleen can represent direct invasion from adjoining organs such as the pancreas but Pancreatic neuroendocrine tumour presenting as a primary splenic mass is exceptionally rare (6, 7).

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