neurodegenerative disease

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neurodegenerative disease

Any of a group of hereditary and sporadic conditions characterised by progressive dysfunction, degeneration and death of specific populations of neurones which are often synaptically interconnected.

Neurodegenerative diseases
Akinetic-rigid
Examples
Parkinson’s disease, progressive supranuclear palsy, corticobasal degeneration, multisystem atrophy with striatonigral degeneration.

Clinical findings
Bradykinesia, rigidity.

Location
Substantia nigra, basal ganglia.

Hyperkinetic
Examples
Huntington’s disease, dentatorubropallidoluysial atrophy.

Clinical findings
Choreoathetosis, dystonia.

Location
Basal ganglia.

Ataxic
Examples
Friedrich’s ataxia, spinocerebellar degeneration, dentatorubropallidoluysial atrophy.

Clinical findings
Cerebellar ataxia.

Location
Cerebellum and connecting tracts.

Motor neuron disease
Examples
Amyotrophic lateral sclerosis, spinobulbar muscle atrophy (Kennedy’s disease), spinal muscular atrophy.

Clinical findings
Motor weakness.

Location
Motor system.

Temporoparietal degeneration
Examples
Alzheimer’s disease, dementia with Lewy bodies.

Clinical findings
Memory changes, parietal lobe dysfunction.

Location
Hippocampus, cortical neurons.

Frontotemporal degeneration
Example
Frontotemporal lobar degeneration.

Clinical findings
Apathy, disinhibition, memory changes.

Location
Frontal and temporal cortex.

Multifocal degeneration
Example
Prion disease.

Clinical findings
Variable cortical and subcortical changes.

Location
Cortical, subcortical neurons.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

Neurodegenerative disease

A disease in which the nervous system progressively and irreversibly deteriorates.
Mentioned in: Amnesia
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
AC Immune SA (ACIU) announced dosing of the first subject in a Phase 1 study of ACI-3024, an investigational oral small molecule Tau Morphomer inhibitor that will be studied in neurodegenerative diseases that are characterized by the presence of pathological Tau aggregates.
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Dr Hampel has 25 years clinical trial experience in Alzheimer's disease and related neurodegenerative diseases and has published more than 600 scientific publications and has won multiple awards for his research.
[USA], Feb 16 (ANI): Scientists at the University of Virginia School of Medicine have identified a potential explanation for the mysterious death of specific brain cells seen in Alzheimer's, Parkinson's and other neurodegenerative diseases.
The accumulation of these disease-linked protein complexes is believed to drive the progression of ALS and other neurodegenerative diseases.
Lonza Pharma & Biotech and Denali Therapeutics have formed a partnership on Denali's biologic pipeline products for neurodegenerative diseases. The agreement covers all stages of the development and manufacturing.
HAMBURG, Germany, December 15, 2016 -- Evotec AG announced that it will collaborate with Celgene Corporation to identify disease-modifying therapeutics for a broad range of neurodegenerative diseases.
Multiple studies have indicated that there is a cross talk between systematic inflammation and neuronal damage in neurodegenerative diseases. For instance, in primary neurodegenerative diseases such as PD and AD, the initial event may be a nonimmune-mediated injury within the central nervous system.
The results support the suggestion that elevated ferritin iron and its associated toxicity is a risk factor for age at onset of neurodegenerative diseases such as AD and PD.
In a study published online August 15 in Genome Research, researchers have analyzed changes in gene expression in the aging and diseased brain, finding new clues to the biology of normal aging and neurodegenerative diseases.
Few studies before this one have explained why neurodegenerative diseases attack only certain parts of the brain.