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When including JAK/STAT signaling, they found that spontaneous, noise-induced neuroblast differentiation is cancelled.
littoralis on adult neurogenesis in the DG of the adult mouse hippocampus using 5-bromo-2-deoxyuridine (BrdU, an indicator for cell proliferation) labeling and immunohistochemistry for doublecortin (DCX, an immature neuronal marker), which has been commonly used to investigate the proliferation of neuroblast.[18],[19] In addition, we examined expressional changes of brain-derived neurotrophic factor (BDNF) and its major receptor tropomyosin-related kinase B (TrkB), which are well known to be involved in the neurogenic process.[20],[21]
To analyze the potential effects of probucol on DG neuronal differentiation in YAC128 mice, we used the endogenous marker DCX, a microtubule-binding protein that is expressed in newly differentiated and migrating neuroblasts [61].
Overexpression of cMYC and MYCN in chick sympathetic neuroblasts results in a significant increase in their proliferation in vitro and in vivo, although it does not affect the viability of cells in culture [48].
(2) The neuronalcommitted precursors (neuroblasts) and newly generated immature neurons expressing Notch ligands such as DLL1 activate Notch signaling in neighboring NSCs, producing cleaved Notch (NICD).
Histologic examination of the mass revealed neoplastic proliferation infiltrating the adjacent cerebellar tissue; the mass was composed of a mixture of neuroblasts arranged in a cohesive pattern and numerous cells with neuronal features (ganglion cells) interspersed with delicate stroma.
The histological report described a spindle cell stroma in a fibrillary matrix interspersed with scattered nests of primitive neuroblasts and high proportion of differentiating elements (ganglion cells) (Figure 2), placing the tumor in a favorable subgroup (ganglioneuroblastoma intermixed).
Histologically, their primary features are neuroblasts, ganglion cells, Schwann cells, and stroma.
Caption: FIGURE 4: Neuroblastoma (Schwannian-stroma-poor), differentiating subtype, composed predominantly of differentiating neuroblasts with moderate to abundant acidophilic cytoplasm and enlarged, eccentric nucleus with vesicular chromatin and single prominent nucleolus.
Sampaio et al., "Indomethacin treatment reduces microglia activation and increases numbers of neuroblasts in the subventricular zone and ischaemic striatum after focal ischaemia," Journal of Biosciences, vol.