The effect of a neuroactive steroid
reveals a ligand-receptor interaction.
It is considered both a neurosteroid, being produced in the brain, as well as a neuroactive steroid
, produced in the adrenals and having its effect on the brain.
Sage's most advanced, oral product candidate is SAGE-217, a novel, orally-active neuroactive steroid
that is a positive allosteric modulator of synaptic and extrasynaptic GABAA receptors.
Because it is synthesized directly in the brain, it is referred to as a neuroactive steroid
This increase appears to be mediated by activation of the HPA axis because the increase in neuroactive steroid
levels elicited by these stimuli can be blocked by disruption of the HPA axis via adrenalectomy (O'Dell et al.
6,7) A recent enticing hypothesis proposed that burning mouth syndrome is associated with an alteration of gonadal, adrenal and neuroactive steroid
Numerous studies have provided evidence that this elevation in neuroactive steroid
levels may contribute to various behavioral effects of ethanol by modulating [GABA.
suppression of endogenous hormones, including biologically available testosterone, dehydroepiandrosterone, and other neuroactive steroid
metabolites of progesterone
Anxiolytic effects of the neuroactive steroid
pregnanolone (3 alpha-OH-5 beta-pregnan-20-one) after microinjection in the dorsal hippocampus and lateral septum.
3[alpha]-hydroxy-5[alpha]-pregnan-2[alpha]-one modulates electrophysiological and behavioral actions of ethanol.
GABA(A) receptor-modulating neuroactive steroid
composition in patients with panic disorder before and during paroxetine treatment.
6) Cholesterol is important for brain function and neurotransmission because neuroactive steroids
(NASs) are synthesized from cholesterol and they modulate brain processes and interact with [gamma]-aminobutyric acid, N-methyl-D-aspartate, and serotonin receptors (all of which are implicated in psychiatric disorders) as well as neurotrophins such as nerve growth factor.