The link between testosterone and depression has been debated extensively because testosterone is a neuroactive steroid
hormone known to influence mood and appetitive behavior, Dr.
VistaGen Therapeutics announced that the company has exercised its option to acquire from Pherin Pharmaceuticals the exclusive license for worldwide rights to develop and commercialize PH10, a first-in-class, intranasally administered neuroactive steroid
, with rapid-onset antidepressant effects for treatment of major depressive disorder, or MDD, demonstrated in a phase 2a study.
The effect of a neuroactive steroid
reveals a ligand-receptor interaction.
It is considered both a neurosteroid, being produced in the brain, as well as a neuroactive steroid
, produced in the adrenals and having its effect on the brain.
Sage's most advanced, oral product candidate is SAGE-217, a novel, orally-active neuroactive steroid
that is a positive allosteric modulator of synaptic and extrasynaptic GABAA receptors.
Krishnan et al., "The influence of neuroactive steroid
lipophilicity on GABAA receptor modulation: evidence for a low-affinity interaction," Journal of Neurophysiology, vol.
In fact, administration of systemic progesterone to injured rats produces increases in ALLO levels in neuronal damaged tissues, possibly reflecting a protective effect for this neuroactive steroid
Because it is synthesized directly in the brain, it is referred to as a neuroactive steroid
Effects of chronic ethanol consumption and withdrawal on the neuroactive steroid
3alpha-hydroxy-5alpha-pregnan-20-one in male and female rats.
(6,7) A recent enticing hypothesis proposed that burning mouth syndrome is associated with an alteration of gonadal, adrenal and neuroactive steroid
Conversely, treatment with a neuroactive steroid
that enhances [GABA.sub.A] receptor function increased alcohol intake (Janak and Gill 2003).
DHEA-S and other neuroactive steroid
metabolites of progesterone are suppressed in women taking OCs.