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Steroid produced within the brain.
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It is considered both a neurosteroid, being produced in the brain, as well as a neuroactive steroid, produced in the adrenals and having its effect on the brain.
Sage's most advanced, oral product candidate is SAGE-217, a novel, orally-active neuroactive steroid that is a positive allosteric modulator of synaptic and extrasynaptic GABAA receptors.
Because it is synthesized directly in the brain, it is referred to as a neuroactive steroid or neurosteroid.
This increase appears to be mediated by activation of the HPA axis because the increase in neuroactive steroid levels elicited by these stimuli can be blocked by disruption of the HPA axis via adrenalectomy (O'Dell et al.
6,7) A recent enticing hypothesis proposed that burning mouth syndrome is associated with an alteration of gonadal, adrenal and neuroactive steroid levels.
Numerous studies have provided evidence that this elevation in neuroactive steroid levels may contribute to various behavioral effects of ethanol by modulating [GABA.
suppression of endogenous hormones, including biologically available testosterone, dehydroepiandrosterone, and other neuroactive steroid metabolites of progesterone
Anxiolytic effects of the neuroactive steroid pregnanolone (3 alpha-OH-5 beta-pregnan-20-one) after microinjection in the dorsal hippocampus and lateral septum.
Neuroactive steroid 3[alpha]-hydroxy-5[alpha]-pregnan-2[alpha]-one modulates electrophysiological and behavioral actions of ethanol.
GABA(A) receptor-modulating neuroactive steroid composition in patients with panic disorder before and during paroxetine treatment.
6) Cholesterol is important for brain function and neurotransmission because neuroactive steroids (NASs) are synthesized from cholesterol and they modulate brain processes and interact with [gamma]-aminobutyric acid, N-methyl-D-aspartate, and serotonin receptors (all of which are implicated in psychiatric disorders) as well as neurotrophins such as nerve growth factor.