neuraminic acid

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sialidase

 [si-al´ĭ-dās]
1. an enzyme of the hydrolase class that catalyzes the cleavage of glucosidic linkages between a sialic acid residue and a hexose or hexosamine residue at the nonreducing terminal of oligosaccharides in glycoproteins, glycolipids, and proteoglycans. Deficiency of it is an autosomal recessive trait and is seen in sialidosis and galactosialidosis.
2. the enzyme with this activity specifically cleaving sialic acid–containing gangliosides; it is deficient in mucolipidosis IV. Called also neuraminidase.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

neur·a·min·ic ac·id

(nūr'ă-min'ik as'id),
An aldol product of d-mannosamine and pyruvic acid, linking the C-1 of the former to the C-3 of the latter. The N- and O-acyl derivatives of neuraminic acid are known as sialic acids and are constituents of gangliosides and of the polysaccharide components of mucoproteins and glycoproteins from many tissues, secretions, and species.
Synonym(s): prehemataminic acid
Farlex Partner Medical Dictionary © Farlex 2012

neu·ra·min·ic ac·id

(nūr'ă-min'ik as'id)
An aldol product of d-mannosamine and pyruvic acid. The N- and O-acyl derivatives of neuraminic acid are known as sialic acids and are constituents of gangliosides and of the polysaccharide components of muco- and glycoproteins from many tissues and secretions.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
Sialic acid, which is a derivative of a class of neuraminic acids widely found in the brain and milk of mammals, is an important ingredient to constitute the glycoprotein and glycolipid.
They belong to the family of glycosphingolipids (GSL) and contain one or more sialic acids, N-acetyl derivatives of neuraminic acid, in their hydrophilic oligosaccharide chain.
De-acetylation of the N-acetyl group to an amino group forms neuraminic acid (Neu).
Additionally, dogs and humans express a similar diversity of sialic acid variants and linkages, which have been demonstrated to be important determinants of IAV infection and host range (26), including N-acetyl neuraminic acid and both the [alpha]2-3 and [alpha]2-6 linkages (27,28).
From over 30 acetylated derivatives of neuraminic acid, N-acetylneuraminic acid (referred to as sialic acid) is the most common in humans.
The lectin reactivity of the TF-specific IgG was measured by ELISA in a similar way, except that the binding of neuraminic acid- (sialic acid-) specific Sambucus nigra agglutinin (SNA) and mannose-specific concanavalin A (ConA) to the absorbed serum anti-TF Abs (all isotypes) or anti-TF IgG from tIgG samples was measured as described elsewhere [19, 21].
N-Acetyl neuraminic acid was purchased from Sisco Research Laboratory (Mumbai, India).
Sialic acid comprises of a family of acetylated derivatives of neuraminic acid, which act as acute phase proteins and elevated in numerous inflammatory conditions like diabetes, cancer, and renal diseases.
In SP-HUS, bacterial neuraminidase is thought to cleave N-acetyl neuraminic acid from the surface of red blood cells, platelets, and endothelium, exposing the Thomsen-Friedenreich (T) cryptantigen.
Sialic acid, which is a derivative of acetyl neuraminic acid, attached to non-reducing residues of carbohydrate chain of glycoproteins and glycolipids is found to be elevated in alcohol abuse (8).
GalNAc-GD1a is branched structure containing two neuraminic acid groups at 2 and 4 positions.
To determine the intrinsic adherence of discharging nematocysts, we first measured the adhesive force between maximally sensitized tentacles and gelatin-coated probes in the presence of [10.sup.-5] mol [l.sup.-1] N-acetyl neuraminic acid (NANA), which assures that all of the cnidocyte/supporting cell complexes (CSCCs) are maximally predisposed to discharge in response to the contact stimuli of the probes.