CDH2

(redirected from Neural cadherin)

CDH2

A gene on chromosome 18q11.2 that encodes a calcium-dependent cell–cell adhesion glycoprotein (cadherin), which is involved in regulating cell–cell adhesions, mobility and proliferation of epithelial cells. CDH2 functions during gastrulation and is required for establishing left-right asymmetry. At certain CNS synapses, presynaptic to postsynaptic adhesion is mediated in part by CDH2; in the hippocampus, it may regulate dendritic spine density.
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During this process, E-cadherin, a hallmark of the epithelial phenotype, is downregulated, while neural cadherin (N-cadherin), normally expressed in fibroblasts, is upregulated (Thiery et al., 2009).
Neural cadherin (N-cadherin), caudal type homeobox 2 (CDX2), and insulin-like growth factor II mRNA-binding protein 3 (IMP3) have not been used in larger studies comparing these 2 entities.
N-Cadherin (neural cadherin) is associated with heightened invasive potential in cancer.