RAP programmes consistently earn honors and awards from entities such as ACEEE, AWE, APPA, and NEUAC
2-keto-3-deoxy-D-glycero-D-galac to-nononic acid, a member of the sialic acid family has distinctive properties such as insensitivity to various sialidases and the association of N-acetyl group with the hydroxyl group of NeuAc
(N acetylneuraminic acid) has been shown to be related to human cancers (2-3).
ST6GALNAC1 transfers a sialic acid, N-acetylneuraminic acid (NeuAc
), in an alpha-2,6 linkage to O-linked GalNAc residues [data source: https://string-db.org, version 10.5].
The Trump budget blueprint says that "compared to other income support programs that serve similar populations, LIHEAP is a lower-impact program and is unable to demonstrate strong performance outcomes." The National Energy and Utility Affordability Coalition (NEUAC
) said the program served over 6 million households in 2016 with home-heating and cooling assistance, weatherization, and/or energy-related low-cost home repairs or replacements.
The Trump budget blueprint said that "compared to other income support programs that serve similar populations, LIHEAP is a lower-impact program and is unable to demonstrate strong performance outcomes." According to the National Energy and Utility Affordability Coalition (NEUAC
), in 2016, the program served more than six million households with home heating and cooling assistance, weatherization and/or energy-related low-cost home repairs or replacements.
The National Energy and Utility Affordability Coalition (NEUAC
) said it has urged Congress to provide USD4.7 billion in funding for Low Income Home Energy Assistance Program (LIHEAP) in FY 2016.
N-Acetylneuraminic acid (NeuAc
) is the most common in humans, while N-glycolylneuraminic acid (NeuGc) is not usually detected in normal tissues due to a specific inactivating mutation in the cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMP-NeuAc hydroxylase) gene [8, 9].
Nevertheless, these studies have been restricted to gangliosides containing the N-acetylated variant of sialic acid (NeuAc
) [24, 25].
Regarding sialic acid, the sialyltransferases ST3Gal I, which adds N-acetylneuraminic acid (NeuAc
) to O-linked galactose (Gal) moieties, and ST6GalNAc I, which adds sialic acid to the Tn antigen (GalNAc[alpha]1-O-Ser/Thr), are both upregulated in breast cancer and are associated with aggressive disease and poor prognosis (49-51).
The complex type N-glycan has a common core structure containing 2 N-acetylgalactosamine (G1cNAc) and 3 mannose residues with heterogeneous antennae consisting of G1cNAc, galactose and sialic acid (NeuAc
In addition to the 7 core structures, the Tn (GalNAc[alpha]1-Ser/Thr) and sialyl Tn [NeuAc[alpha]2-6GalNAc[alpha]1-Ser/ Thr; where NeuAc
is N-acetylneuraminic acid (sialic acid)] epitopes can be distinguished.