ERBB2

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ERBB2

A gene on chromosome 17q11.2-q12 that encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ERBB2 has no ligand-binding domain and thus cannot bind growth factors; it does, however, bind to other ligand-bound EGF receptor family members, forming a heterodimer, stabilising ligand binding and enhancing kinase-mediated activation of downstream signalling pathways (e.g., those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase).

Molecular pathology
ERBB2 amplification and overexpression commonly occurs in breast and ovarian cancers.
References in periodicals archive ?
Mi allai arbed i rai ohonyn nhw fynd ar gwrs Wlpan neu i Nant Gwrtheyrn (oes unrhyw rai ohonyn nhw'n trafferthu dyddie 'ma?
Neu Kaliss Spezialpapier belongs to the Melitta-Group, which is a family owned company with brands including Melitta Coffee, Toppits, Swirl and HandyBag.
Currently, Dr Neu serves as a managing director of Baker Brothers Investments.
Ond hyd yn oed wedyn, triwch chi enwi holl aelodau'r Cyrff, neu'r Fflaps, neu Maffia Mr Huws, neu Elfyn Presli?
When the HER2/ neu and CEP17 copy numbers as well as the ratio of HER2/ neu to CEP17 signals were compared between the IHC 2007 and IHC 2013 groups (Tables 5 and 6), no statistical differences among the IHC groups were detected.
Gallwch newid eich cyflenwr ynni ar lein, neu gallwch ffonio'r cwmniau'n uniongyrchol.
Different parameters determine the prognosis of bladder carcinoma, including stage, grade, patient`s age2, lymph node status, HER 2/ neu and p53 expression3.
Yr unig beth hoffwn ei ychwanegu i drafodaeth Gwanas yw mae'n weddol amlwg i mi nad yw pobl sydd yn ymroi yn llawn amser ac yn broffesiynol yn y Maes Diwylliant Cymraeg yn cael eu talu yn iawn am eu (ein) gwaith, neu fydda ddim rhaid rhedeg o gwmpas cymaint yn gweithio er mwyn talu'r bali biliau.
A NEU Homes project manager will coordinate the service providers required for your project, including introductions to the following: realtor, general contractor, architect, loan experts, HUD consultant, closing attorney, interior designer, insurance agent, home inspector, landscape design and installation, pool installation, movers, and Individual craftsmen such as: roofers, flooring companies and carpenters.
Impact of polysomy 17 on HER-2/ neu immunohistochemistry in breast carcinomas without HER-2/neu gene amplification.
The role of the NEU is to design, develop and deliver the new examinations and manage the marking process to ensure transparency, consistency, reliability and accuracy of results and information," she said.
We were very surprised to see such a response in these patients with low-expressing HER2 / neu tumors, and we are very excited with these results," Dr.