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Diffusible proteins that provide chemotactic cues to guide axons. Netrin-1 is made by and secreted from floor plate cells of the neural tube. Netrin-2 is synthesized in the lower regions of the neural tube.
References in periodicals archive ?
Netrin-1 increases proliferation and migration of renal proximal tubular epithelial cells via the UNC5B receptor.
Netrin-1 rescues neuron loss by attenuating secondary apoptosis in ipsilateral thalamic nucleus following focal cerebral infarction in hypertensive rats.
Indeed, different A[beta]PP ligands have been identified, such as A[beta] [51], netrin-1 [52], and F-spondin [53].
In knockout mice of Netrin-1 and DCC, although PN neurons can leave their site of birth and migrate anteriorly, they fail to reach the midline.
After this screening process, one molecule emerged: netrin-1.
Netrin-1 is a novel myelin-associated inhibitor to axon growth.
They discovered that cholesterol-filled cells called macrophages secrete a product called netrin-1, which prevents them from leaving the arteries.
Recent studies found that the DCC gene is involved in the regulation of axonal development as a component of the Netrin-1 receptor (Fazeli et al.
In the study, scientists have shown that APP binds to netrin-1, a protein that helps to guide nerves and their connections in the brain, as well as helping nerve cells to survive.
tyrosine phosphatase beta Matrilin 2 1e-34 Collagen XXIX alpha 1 Netrin G1 0 Human netrin-1 Osteomodulin 3e-27 Similar to insulin-like growth factor binding protein, acid labiles subunit (IGFALS) Podocan 1e-40 Leucine-rich-repeat cont.
The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons.