She is being honored for her project on how Hypoxia sustains low-grade inflammation by inducing Netrin-1
expression in adipose tissue resident macrophages in obesity.
is a novel myelin-associated inhibitor to axon growth.
Recent studies found that the DCC gene is involved in the regulation of axonal development as a component of the Netrin-1
receptor (Fazeli et al.
In the study, scientists have shown that APP binds to netrin-1, a protein that helps to guide nerves and their connections in the brain, as well as helping nerve cells to survive.
When netrin-1 was given to mice that have a gene for Alzheimer's disease their symptoms were reversed, and the sticky amyloid was reduced.
For instance, laminin alone is trophic and netrin-1 alone is an attractant, but together they can modulate an inhibitory response of the axon.
2000) showed that dorsal thalamic axons favor the chemoattractant netrin-1 by demonstrating the disorganized and abnormal pathways that develop without it.
The researchers focused on a possible conditional-suppressor gene called DCC, which stands for "deleted in colorectal cancer," and a protein called netrin-1.
DCC codes for a cell-surface receptor that binds to netrin-1, which scientists had previously linked to nervous system development.
6 The Mechanistic Study of Netrin-1
Protective Effects against Ischemic Stroke
Ramkhelawon and her team previously uncovered a relationship between the body's clean-up cells and a substance called Netrin-1
, which prevents the body from carrying away fatty tissues and unwanted fat cells.
12 Cell describe the proteins, netrin-1
and netrin-2, and their close similarity to the protein unc-6, known to be a key factor in the neural development of the nematode, or common roundworm.