increases proliferation and migration of renal proximal tubular epithelial cells via the UNC5B receptor.
rescues neuron loss by attenuating secondary apoptosis in ipsilateral thalamic nucleus following focal cerebral infarction in hypertensive rats.
Indeed, different A[beta]PP ligands have been identified, such as A[beta] , netrin-1
, and F-spondin .
In knockout mice of Netrin-1
and DCC, although PN neurons can leave their site of birth and migrate anteriorly, they fail to reach the midline.
After this screening process, one molecule emerged: netrin-1
is a novel myelin-associated inhibitor to axon growth.
They discovered that cholesterol-filled cells called macrophages secrete a product called netrin-1
, which prevents them from leaving the arteries.
Recent studies found that the DCC gene is involved in the regulation of axonal development as a component of the Netrin-1
receptor (Fazeli et al.
In the study, scientists have shown that APP binds to netrin-1
, a protein that helps to guide nerves and their connections in the brain, as well as helping nerve cells to survive.
tyrosine phosphatase beta Matrilin 2 1e-34 Collagen XXIX alpha 1 Netrin G1 0 Human netrin-1
Osteomodulin 3e-27 Similar to insulin-like growth factor binding protein, acid labiles subunit (IGFALS) Podocan 1e-40 Leucine-rich-repeat cont.
Function in the Adult Rat Central Nervous System"
The axonal chemoattractant netrin-1
is also a chemorepellent for trochlear motor axons.