Growth cone attraction to netrin-1
is converted to repulsion by laminin-1.
The researchers focused on a possible conditional-suppressor gene called DCC, which stands for "deleted in colorectal cancer," and a protein called netrin-1
. Previous research suggested that DCC acts as a tumor-suppressor gene because, as its name implies, it's frequently missing in people with colorectal cancer.
increases proliferation and migration of renal proximal tubular epithelial cells via the UNC5B receptor.
Holt, "Asymmetrical i-actin mRNA translation in growth cones mediates attractive turning to netrin-1
," Nature Neuroscience, vol.
He et al., "Netrin-1
hyperexpression in mouse brain promotes angiogenesis and long-term neurological recovery after transient focal ischemia," Stroke, vol.
Ramesh, "Kidney proximal tubular epithelialspecific overexpression of netrin-1
suppresses inflammation and albuminuria through suppression of COX-2-mediated PGE2 production in streptozotocin-induced diabetic mice," The American Journal of Pathology, vol.
Liu et al., "Netrin-1
promotes cell migration and invasion by down-regulation of BVES expression in human hepatocellular carcinoma," American Journal of Cancer Research, vol.
It was shown in previous studies that many mediators produced or expressed in the corneal epithelium were effective in regulating inflammatory response and maintaining the homeostasis of the ocular surface, such as Resolvin D1, Resolvin E1, IL1RA, Netrin-1
, and UNC5B.
, a secreted laminin-related molecule, was originally identified as an important guidance molecule in the nervous system .
12 Cell describe the proteins, netrin-1
and netrin-2, and their close similarity to the protein unc-6, known to be a key factor in the neural development of the nematode, or common roundworm.
Binding of DCC by netrin-1
to mediate axon guidance independent of adenosine A2B receptor activation.
By activating p38 MAPK and PI3K-Akt signal cascades, Netrin-1
could enhance SCs migration .