netilmicin


Also found in: Dictionary, Wikipedia.
Related to netilmicin: Netilmicin sulfate

aminoglycoside

 [ah-me″no-gli´ko-sīd]
any of a group of antibacterial antibiotics derived from species of Streptomyces; they interfere with the function of bacterial ribosomes. They contain an inositol moiety substituted with two amino or guanidino groups and with one or more sugars or aminosugars. The group includes amikacin, gentamicin, kanamycin, neomycin, streptomycin, and tobramycin. They are used to treat infections caused by gram-negative organisms and are classified as bactericidal agents because of their interference with bacterial replication. All are highly toxic, requiring frequent monitoring of blood serum levels and careful observation of the patient for early signs of toxicity, particularly ototoxicity and nephrotoxicity.

netilmicin

An AMINOGLYCOSIDE antibiotic drug derived from gentamicin. It is slightly less likely to damage the kidneys than gentamicin and is often effective against organisms resistant to that drug. A brand name is Netillin.
References in periodicals archive ?
CLSI disc diffusion method Antimicrobial (interpretation) Ampicillin R Chloramphenicol R Ciprofloxacin R Cotrimoxazole R Co-amoxiclav R Cefotaxime R Cefixime R Cefepime R Aztreonam R Imipenem S Meropenem S Ertapenem S Amikacin S Netilmicin S R, resistance; S, susceptible.
strain showed resistance to the following: ampicillin (AMP), amoxicillin-clavulanate (AMC), cefalotin (CF), piperacillin (PIP), piperacillin-tazobactam (TZP), cefuroxime (CXM), cefoxitin (FOX), cefotaxime (CTX), ceftriaxone (CRO), aztreonam (ATM), ceftazidime (CAZ), cefepime (FEP), imipenem (IPM), meropenem (MEM), ertapenem (ETP), trimethoprim-sulphamethoxazole (SXT), amikacin (AK), tobramycin (NN), netilmicin (NET), ampicillin-sulbactam (SAM), ciprofloxacin (CIP), chloramphenicol (C).
(9) The isolates were tested for susceptibility to amikacin (AMK), amoxicillin/clavulanic acid (AMC), ampicillin (AMP), ampicillin/sulbactam (SAM), aztreonam (ATM), cefepime (FEP), cefotaxime (CTX), cefoxitin (FOX), ceftazidime (CAZ), ciprofloxacin (CIP), imipenem (IMP), meropenem (MEM), netilmicin (NET), and piperacillin/tazobactam (PTZ).
According to Proteus mirabilis (16%), Klebsiella pneumoniae (19%) and Pseudomonas aeruginosa (26%) resistance to netilmicin, this drug has similar antibacterial spectrum to that of gentamicin, with the same nephro/oto/vestibulotoxicity disadvantages.
High resistance was found for amoxicillin/clavulanic acid, 82.7%, cefipime, 79.3%, netilmicin, 72.4% and azetreonam, 55.1%.
Drug resistance to amikacin, tobramycin, netilmicin, ciprofloxacin, and levofloxacin was significantly changed after recurrent infection.
aureus observed for various antibiotics were as follows: amoxicillin (20.9%), erythromycin (8.8%), clindamycin (5%), cefotaxime (3.7%), gentamicin (3%), ciprofloxacin (2.4%), rifampicin (1%), netilmicin, and 5 (0.3%).
He had used dexamethasone/ netilmicin combination and ketorolac drops, which were not prescribed by a physician.
Susceptibility to different antibiotics such as amikacin, netilmicin, levofloxacin, piperacillin-tazobactam, cefotaxime, ceftazidime, cefepime, tobramycin, imipenem, meropenem, and colistin was determined by disk diffusion testing according to Clinical and Laboratory Standards Institute (CLSI) guidelines (M100-S23 2013) [25],
baumannii infections was 95.5% for ciprofloxacin, 72.7% for cefepime, 80.3% for imipenem, 17.2% for meropenem, 68.2% for cefoperazone/sulbactam, 30.3% for netilmicin, 25.8% for tigecycline, and 0% for colistin.
aureus Surgical Oxa, Gen, Tob, Ami, Kan, Sis, Neo, Para, But, Sa358 wound Net Ast = aztreonan; Ax = amoxicillin; Amp = ampicillin; Ami = amikacin; Amox = amoxicillin; Ca = cefadroxil; Cfr = cefaclor; Cf = cefalothin; Caz = ceftazidime; Cip = ciprofloxacin; Chl = chloramphenicol; Im = imipenem; Kan = kanamycin; Szt = sulfametrim; Tc = tetracycline; Tob = tobramycin; Oxa = oxacillin; Gen = gentamicin; Sis = sisomicin; Neo = neomycin; Para = paramomycin; But = butirosin; Net = netilmicin. Table 2.
Standard antibiotics such as netilmicin, 5-flucytocine and itraconazole were used as positive controls, for the antibacterial and antifungal activity.