nephrogenic systemic fibrosis


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nephrogenic systemic fibrosis

A rare condition linked to gadolinium-based MRI contrast solutions—in particular Omniscan and OptiMARK, which have a linear non-ionic structure and more likely to release Gd3+ to tissue—characterised by fibrosis of skin, joints, eyes and internal organs, resulting in scleromyxedema/papular mucinosis-like histologic appearance, limitation of joint movement, kidney failure and, in extreme cases, systemic fibrosis affecting the lungs, heart and liver.
 
Prevention
Some protection may be provided by diethylene-triaminepentaacetic acid.
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References in periodicals archive ?
Nephrogenic systemic fibrosis: suspected causative role of gadodiamide used for contrast-enhancing magnetic resonance imaging.
Gadolinium-contrast toxicity in patients with kidney disease: nephrotoxicity and nephrogenic systemic fibrosis. Curr Drug Saf 2008; 3:67-75.
Jimenez, "NFkappaB activation and stimulation of chemokine production in normal human macrophages by the gadolinium-based magnetic resonance contrast agent Omniscan: possible role in the pathogenesis of nephrogenic systemic fibrosis," Annals of the Rheumatic Diseases, vol.
Kay, "Nephrogenic systemic fibrosis: a gadolinium-associated fibrosing disorder in patients with renal dysfunction," Annals of the Rheumatic Diseases, vol.
Fiorentino, "Nephrogenic systemic fibrosis: relationship to gadolinium and response to photopheresis," Archives of Dermatology, vol.
Nephrogenic systemic fibrosis: Pathogenesis, diagnosis and therapy.
Finally, nephrogenic systemic fibrosis is a systemic fibrosing condition that occurs in people with kidney disease.
Kidney patient Margaret Roxburgh, 54, was diagnosed with nephrogenic systemic fibrosis days after being injected with Omniscan.
Nephrogenic systemic fibrosis (NSF) is a recently identified fibrosing disorder affecting patients with chronic kidney disease and occasionally those with acute renal failure.
CHICAGO -- Few physicians would be fooled nowadays by gadolinium-induced nephrogenic systemic fibrosis, but there are other diseases that can masquerade as scleroderma.
One rare but serious concern with MRA is that contrast agents may cause nephrogenic systemic fibrosis (NSF), a debilitating and sometimes fatal diffuse disease affecting the skin, muscle, and internal organs.