nephrogenic adenoma

(redirected from Nephrogenic metaplasia)

neph·ro·gen·ic ad·e·no·ma

a benign tumor of the urinary bladder or urothelium, composed of glandular structures resembling renal tubules.

nephrogenic adenoma

A benign lesion which is more common in women and arises in urothelium-lined structures, especially the bladder, which often contains scant amounts of crystalloid material. It is regarded as a metaplastic response to mechanical trauma—e.g., recurrent UTIs, stones, diverticuli, urinary tract instrumentation, ulcers, infection, ureteric stents, intravesical therapy and open bladder surgery.

DiffDx
Prostate adenocarcinoma (tubular structures), clear cell (hobnailing) carcinoma, in situ adenocarcinoma. 

Presence of tubules, cords, and signet ring-like cells; prominent nucleoli; muscle involvement; blue-tinged mucinous secretions; focal prostate specific antigen and PSAP positivity; and negative staining for high molecular weight CK (34betaE12).
References in periodicals archive ?
The keywords used included nephrogenic adenoma of urinary bladder and nephrogenic metaplasia of urinary bladder.
i) nephrogenic metaplasia or nephrogenic adenoma of the urinary tract may present a diagnostic challenge in the practice of surgical pathology;
ii) previous case reports had suggested the possibility of nephrogenic metaplasia progressing to clear cell adenocarcinoma; nevertheless, a malignant potential of nephrogenic metaplasia had not been generally acknowledged.
A few entities come into the differential diagnoses of nephrogenic metaplasia.
Additional studies are necessary to further elucidate the preneoplastic potential of nephrogenic metaplasia.
The atypical nephrogenic metaplasia is recognized as benign with the occasional substantial cytological abnormalities of no apparent clinical significance.
Nephrogenic metaplasia of urinary tract in children: report of three cases and review of the literature.
This variant of urothelial bladder cancer often resembles clinical and histological features of inverted papilloma, von Brunn's nests (VBNs), cystitis cystica, nephrogenic metaplasia and sometimes usual TCC.
This is confirmed by the difficult differential diagnosis between these histological appearance and lesions, such as inverted papilloma, VBNs, cystitis cystica and nephrogenic metaplasia.
Nephrogenic metaplasia is another term that is commonly used for this lesion.
These neoplasms are lined by urothelium, unlike the cuboidal or columnar single cell lining the papillae in nephrogenic metaplasia, and are usually not difficult to distinguish from NA.
Within the differential are normal urothelial cells from deeper layers, florid intestinal metaplasia (cystitis glandularis), low-grade transitional cell carcinoma with glandular metaplasia, and nephrogenic metaplasia or so-called nephrogenic adenoma.