Antiangiogenic and antimetastatic properties of Neovastat
(Ae-941) an orally active extract derived from shark cartilage.
Washington, May 27 (ANI): Shark cartilage extract, AE-941 or Neovastat, has shown no benefit as a therapeutic agent when combined with chemotherapy and radiation for patients with advanced non-small cell lung cancer, say researchers at The University of Texas MD Anderson Cancer Center.
A unique and important aspect about this shark cartilage study was that this product, Neovastat, was never sold over-the-counter, unlike other shark cartilage compounds previously studied.
Another NCI-sponsored study evaluating Neovastat
(AE-941), an angiogenesis inhibitor derived from ultrafiltration of liquid dogfish shark cartilage, is ongoing.
Its experimental drug, called Neovastat
, is "not like the powdered cartilage that you find in health food stores;' explains company spokesman Paul Burroughs.
has been developed as a pharmaceutical, going through phase I and II studies, he explained.
Affinitak, Aptosyn, Bevacizumab, Carboxyamidotriazole, Cetuximab, CI-994, Docetaxel, Efaproxyn, Erlotinib, Gefitinib, Gemcitabine, Genasense, Lapatinib IGN-101, Mitumomab, Neovastat
, Paclitaxel, Panitumumab, Pemetrexed, Targretin, Telcyta, Tirapazamine, Trastuzumab, Vinflunine, Vinorelbine, Xcytrin, ZD-6474
2-methoxyestradiol, AMG-706, ATN-161, AZD-2171, bevacizumab, combretastatin A-4 prodrug, enzastaurin hydrochloride, everolimus, neovastat
, PTK/ZK, sorafenib tosylate, squalamine, thalidomide, vitaxin, XL-999, ZD-6474, volociximab etc.
New top class drugs such as Angiozyme, BAY 43-9006, Neovastat
, Tarceva, Flavopiridol, PTK787 together with Avastin, Gleevec, Iressa and Erbitux have been included in this progression analysis.
Among the most prominent ones Avastin, Neovastat
and Vatalanib can be found.
Clinical Trial Data In Prolonging Cancer Survival Times