neoadjuvant chemotherapy


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neoadjuvant chemotherapy

Chemotherapy given before cancer surgery with the hope that it will shrink the tumour, resulting in a procedure that is less drastic and has clearer margins.

Indications
Breast, colorectal, lung cancers.

Adverse effects
Nausea, vomiting, hair loss, fatigue, oral ulcers, infection, anaemia, increased bleeding.

neoadjuvant chemotherapy

Induction chemotherapy, neoadjuvant therapy, preemptive chemotherapy, primary chemotherapy Oncology 1. The use of chemotherapy on solid–ie, non-hematopoietic neoplasms–eg, osteosarcomas, anal cancer, head&neck cancer; NC is used in Pts with clinically resectable but locally advanced disease that is not amenable to complete eradication surgery or RT; agents used in NC include cisplatin, 5-FU, vinblastine, and the M-VAC 'cocktail.' See Neoadjuvant therapy. Cf Induction therapy.

Neoadjuvant chemotherapy

Treatment of the tumor with drugs before surgery to reduce the size of the tumor.
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References in periodicals archive ?
Neoadjuvant chemotherapy and/or radiotherapy may be considered for LRCC; however, little evidence is available due to a lack of prospective trials.
Surgical Resection with Neoadjuvant Chemotherapy for Locoregionally Recurrent Appendiceal Cancer Invading the External Iliac Vessels
How often does neoadjuvant chemotherapy avoid axillary dissection in patients with histologically confirmed nodal metastases?
Sentinel lymph node biopsy and neoadjuvant chemotherapy in the management of early breast cancer: safety considerations and timing
Pathologic downstaging is a surrogate marker for efficacy and increased survival following neoadjuvant chemotherapy and radical cystectomy for muscle-invasive urothelial bladder cancer.
Kas Ynvaz Mesane Kanserinde Risk Adaptif Neoadjuvan Kemoterapi/Risk Adaptive Neoadjuvant Chemotherapy in Muscle Invasive Bladder Cancer
The addition of trastuzumab to the neoadjuvant chemotherapy significantly improved the pCR rate.
Neoadjuvant chemotherapy with trastuzumab in HER2-positive breast cancer: pathologic complete response rate, predictive and prognostic factors
To find out whether Ki-67 mRNA expression has a relationship with clinical response to neoadjuvant chemotherapy in breast cancer, we used bivariate analysis, which can be seen in Table 3.
Ki-67 Expression by Immunohistochemistry and Quantitative Real-Time Polymerase Chain Reaction as Predictor of Clinical Response to Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer
Rea, "Neoadjuvant Chemotherapy in Triple Negative Breast Cancer: An Observational Study," Oncology Research : Featuring Preclinical and Clinical Cancer Therapeutics, vol.
PD-L1 Expression in TNBC: A Predictive Biomarker of Response to Neoadjuvant Chemotherapy?
Prognostic factors for osteosarcoma of the extremity treated with neoadjuvant chemotherapy: 15-year experience in 789 patients treated at a single institution.
Histopathologic Features of Prognostic Significance in High-Grade Osteosarcoma
The long-term efficacy of neoadjuvant chemotherapy followed by radical hysterectomy compared with radical surgery alone or concurrent chemoradiotherapy on locally advanced-stage cervical cancer.
Cervical cancer along with unknown cirrhosis: a misdiagnosed case
Results: The results showed that among the 20 patients who underwent neoadjuvant chemotherapy no one had complete response, 55% had partial response, 35% had stable disease, and 2 had progressive disease and were advised palliative radiotherapy only.
Neoadjuvant chemotherapy: role in locoregionally advanced oral cancers
"As Principal Investigator for the Phase Ib dose-escalation OVATION 1 study evaluating patients newly diagnosed with Stage III/IV ovarian cancer and treated with four different doses of GEN-1, in combination with neoadjuvant chemotherapy, I was encouraged by this promising data.
Celsion says GEN-1 immunotherapy highlighted in Oppenheimer expert call
However, there is no published data comparing treatment by neoadjuvant chemotherapy or hypofractionation with standard concomitant chemoradiation.
A STUDY COMPARING THREE DIFFERENT CHEMO-RADIATION TECHNIQUES IN MANAGEMENT OF CERVICAL CANCER
Neoadjuvant chemotherapy is given before local advanced breast cancer surgery.
Comparison of MRI and US in Tumor Size Evaluation of Breast Cancer Patients Receiving Neoadjuvant Chemotherapy

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