NEMO

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NEMO

NF-kB Essential Modulator. A regulatory sub-unit of the inhibitor of NF-kappaB kinase (IKK) complex encoded by IKBKG on chromosome Xq28,  which activates NF-kappaB, triggering activation of genes involved in inflammation, immunity, cell survival, and other pathways. NEMO has an antiapoptotic function independent of its role in the IKK pathway, which prevents receptor-interacting protein-1 (RIP1) from engaging caspase-8 before IKK-mediated induction of antiapoptotic genes. Without NEMO, RIP1 associates with caspase-8, resulting in rapid TNF-induced apoptosis.
 
Abnormal in
IKBKG mutations are linked to incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several immunodeficiencies.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
At just 3.86 metres in length, 1.72 metres high and 1.72 metres wide, Nemo is capable of carrying loads up to the capacity of 2.8 cubic metres and 2.5 metres in length.
I did some long trips in Nemo and unlike some other vans I have driven, you step out after 100 miles thinking you have covered just 10.
The Nemo offers even more friendliness with storage compartments and cubby-holes dotted around the cabin.
The automaker insists that the Nemo is geared towards both short and long-haul deliveries, thanks to its responsive engines and excellent fuel economy.
Priced from pounds 7995 plus VAT and delivery, the new four-model Nemo range includes X and LX trim levels.
Access to the load compartment is via two hinged rear doors which open a full 180 degrees and, to make things easy, the Nemo comes with a low sill height.
Spears and Williams, both former Blimpie franchise owners, invested $250,000 from personal savings, proceeds from the sale of their Blimpie properties, and a home equity loan to turn an old Chinese restaurant into the first Nemos Seafood.
Interested in becoming a Nemos Seafood franchise owner?
Nemos Seafood owners Spears and Williams offer this advice:
Although this clownfish-buying fad seems innocent, it poses real harm to tropical reef ecosystems--the natural home of Nemo and his friends.
Another risk of the Nemo craze is to the fish themselves.
David Helvarg, president of the Blue Frontier Campaign, compares the current interest in buying Nemo with the rush to purchase Dalmatian puppies after the release of 101 Dalmatians.