Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.
the development of an ACTH-producing pituitary tumor after bilateral adrenalectomy in Cushing's syndrome; it is characterized by aggressive growth of the tumor and hyperpigmentation of the skin.
Etymology: Donald H. Nelson, American physician, b. 1925
a pituitary adenoma that may follow bilateral adrenalectomy for Cushing's syndrome. It is characterized by a marked increase in the secretion of adrenocorticotropic hormone and melanocyte-stimulating hormone by the pituitary gland and visual problems because of optic chiasm compression. Treatment includes irradiation to decrease pituitary function and in some cases hypophysectomy. See also Cushing's disease.
Nelson's syndromeA late complication of removal of both adrenal glands for CUSHING'S SYNDROME. A rapidly growing, invasive tumour of the PITUITARY GLAND occurs, releasing hormones that produce intense brown pigmentation of the skin. (Don H. Nelson, American physician, b. 1925).
the development of an ACTH-producing pituitary tumor after bilateral adrenalectomy in Cushing's syndrome.