nelfinavir

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Related to Nelfinavir mesylate: Viracept

nelfinavir

 [nel-fin´ah-vir]
an HIV protease inhibitor used as the mesylate salt in treatment of human immuno deficiency virus infection and acquired immunodeficiency syndrome; administered orally.

nelfinavir

/nel·fin·a·vir/ (nel-fin´ah-vir) an HIV protease inhibitor that causes formation of immature, noninfectious viral particles; used as the mesylate salt in the treatment of HIV infection.

nelfinavir

(nĕl-fĭn′ə-vîr)
n.
A protease-inhibiting drug given in the form of its mesylate, often with other drugs, to suppress the replication of HIV.

nelfinavir

an antiviral.
indications It is used alone or in combination with other drugs to treat HIV.
contraindication Known hypersensitivity to protease inhibitors prohibits its use.
adverse effects Life-threatening effects include anemia, leukopenia, thrombocytopenia, and hemoglobin abnormalities. Other adverse effects include anorexia, dyspepsia, headache, asthenia, poor concentration, dermatitis, pain, bleeding, hypoglycemia, and hyperlipidemia. Common side effects include diarrhea, flatulence, and rash.

nelfinavir

A potent HIV protease inhibitor, which is combined with reverse transcriptase inhibitors—e.g., Retrovir (AZT), zidovudine and Epivir (3TC, lamivudine)—acting at late stages in the HIV life cycle.
 
Side effects
Diarrhoea, 20%, increased liver function tests (LFTs), lipodystrophy.
 
Contraindicated drugs
Nelfinavir inhibits the cytochrome P-450 system, precluding co-administration of agents (e.g., amiodarone, astemizole, cisapride, ergot derivatives, midazolam, quinidine, rifampin, terfenadine, triazolam) which are metabolised by the P-450 system.

nelfinavir

Viracept® AIDS A potent HIV protease inhibitor, used with reverse transcriptase inhibitors–eg, Retrovir–AZT, zidovudine and Epivir–3TC, lamivudine; it acts at late stages in the viral life cycle Side effects Diarrhea–20%, ↑ LFTs, lipodystrophy. See AIDS, Antiretroviral, HIV, Protease inhibitors. Cf Reverse transcriptase inhibitor.

nelfinavir

A protease inhibitor drug used in combination with other antiretroviral drugs to treat HIV infections. The drug is on the WHO official list. A brand name is Viracept.
References in periodicals archive ?
A stock solution containing indinavir sulfate, nelfinavir mesylate, ritonavir, and saquinavir mesylate was prepared in methanol.
Nelfinavir mesylate increases saquinavir-soft gel capsule exposure in HIV1 patients [Abstract].