In clinical studies, it is claimed to have shown efficacy for both the positive symptoms (such as hallucinations or delusions) and negative symptoms
(such as blunted affect or avolition) of schizophrenia.
The company said, "Anticipated Clinical Milestones: Roluperidone: Phase 3 trial to treat negative symptoms
in patients diagnosed with schizophrenia; completion of enrollment in this trial is expected during the second half of 2019, with top line results from the 12-week double blind phase of this trial expected in the fourth quarter of 2019.
of schizophrenia--such as social withdrawal, avolition, avoidance, lack of spontaneity, anhedonia, poverty of speech, and blunted affect--often persist after successful treatment of positive symptoms, such as hallucinations and delusions.
Keywords: Positive and Negative Symptoms
, In-door and out-door setting, Acute and chronic, Single and multiple episodes, Schizophrenia patients.
Research shows that side effects from prescribed medication and negative symptoms
of the illness can lead to increased risks of long-term health conditions that impact on life expectancy.
(3) Patients with stable-poor PMA had significantly more severe negative symptoms
in their second- and third-year course than patients with stable-good PMA, whereas patients with good PMA had fewer negative symptoms
even in their third year of follow-up.
Primary negative symptoms
of schizophrenia are not secondary to extrapyramidal, depressive or positive symptoms (1,2).
 Here, we are presenting a case of posterior fossa arachnoid cyst which presented as severe negative symptoms
The Positive and Negative Syndrome Scale (PANSS) and Scale for the Assessment of Negative Symptoms
(SANS) were used to evaluate the clinical effects of rTMS on SZ.
have a profound impact on long-term outcomes (Hunter & Barry, 2012), and also on lifestyle and general health (Fonseca-Pedrero, 2018; Garcia-Portilla & Bobes, 2013).
Effectiveness of INT on Negative Symptoms
Assessed by PANSS.