negative selection


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negative selection

The process by which immature T lymphocytes (thymocytes) with receptors for autoantigens are destroyed in the thymus. It is part of the mechanism that prevents autoimmune diseases.
See: autoimmunity
See also: selection
References in periodicals archive ?
Our objectives is to maximize coverage of detectors and minimize the overlap, a Differential Evolution based Constrain Multiple-Objective Optimization Problem (DE-CMOP) way is used to improve the Negative Selection Algorithm to optimize generation of the detectors.
Keywords: Wireless Sensor Networks, R-Contiguous bit matching Security, Negative Selection, Attack Detection.
Furthermore, red-crowned cranes exhibited negative selection of fishponds in December and no selection in January (Table II, Table III).
Results of various studies (Kimura, 1983; Nei, 1987; Li, 1997) suggest that rate of amino acid substitution is determined by the stringency of structural and functional constraints and hence proteins having very stringent structural and/or functional requirements, is subject to a strong negative selection pressure limiting the number of changes in the gene product.
The adaptive immune system has three principal processes (Timmis, Hone, Stibor, & Clark, 2008): negative selection, clonal selection and immune network.
Self-oriented perfectionism and a tendency for successful learning and the negative to negative selection to predict.
negative selection, when professionals are automatically screened off and the higher the post the less professional is its holder.
SHOCKER Garrido Negative selection on the left wing, never added anything in attack and spectated in defence
For example, if the brightest people--those who would have earned more regardless of location--were the most likely to move to the United States, then a naive estimate of the return to migration will be biased upward; likewise, the return to migration will be biased downward in the case of negative selection.
The Negative Selection approach (NSA) explains how T-cells are being selected and their maturation in the system.
Selectable marker genes are principally divided into positive or negative selection markers.
It runs a high frequency mean reversion model to avoid situations where a client may be trading away from fair value, if there is inefficient trading in the market or if there is a risk of negative selection.