HIV-1 gene

(redirected from Nef)
Also found in: Dictionary, Acronyms, Wikipedia.

HIV-1 gene

Any of the genes present in the human immunodeficiency virus. See AIDS.
HIV genes
art/trs gene rev gene, see there.
env gene Encodes viral coat proteins gp 120 and gp 41, which mediate CD4 binding and membrane fusion, controlled by tat and rev
gag gene Encodes nucleocapsid core proteins including p24
nef gene 3´ orf, B gene, ORF-2 gene Encodes a protein of unknown function found in infected Pts that may down-regulate viral expression–nef deletion results in a five-fold increase in viral DNA synthesis and replication
pol gene Encodes reverse transcriptase, protease, integrase and ribonuclease
R gene Encodes TAR–transcription activating response element, which has a nonspecific immunodeficiency effect
rev gene art/trs gene Encodes a 19 kD post-transcriptional protein regulator required for HIV replication, up-regulating HIV synthesis by transactivating anti-repression, ↑ levels of envelope RNA by regulating the env gene; inactivation of rev prevents viral replication–as measured by the successful production of the p24 glycoprotein by infected monocytes can be massively ↑ by adding cytokines to culture medium
tat gene Encodes a potent 14 kD transcription activator that amplifies HIV replication, the inactivation prevents viral replication
vif gene Facilitates infectivity of free HIV
vpr gene Encodes a weak transcription activator
vpu gene Unique to HIV-1, encodes a 16 kD product which, when mutated, has a 5-10-fold Ø in replicative capacity and is critical for efficient budding of virions NEJM 1991; 324:308rv
†Gene encoding regulatory protein
‡Gene encoding structural protein
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
Mentioned in ?
References in periodicals archive ?
A nef and good divisor on a complete normal variety is semiample if and only if the associated graded algebra R(X, D) is finitely generated over the base field, see for example [MR] (and also [Zar], [Wil], [Rus], [Laz, I.2.3.15] for the case of nef and big divisors).
Hagan said LISC and NEF have for more than 25 years worked to promote permanent supportive housing for the homeless, the disabled and others with special needs.
MQ Power will be equipping the lower output KD generator sets with Iveco Motors NEF model 45TM1 and NEF 45TM2 diesels.
This reticence to display his erudition is both curious and uncharacteristic, as his Nef des princes a year earlier lists several misogynistic passages from classical and modern sources, albeit in Latin, (2) and adds his own French translation of Matheolus's Malice des femmes.
(19.) Nonconventional Exploitation Factors (NEF) Modeling, ORD 257-96, August 1996.
Simms, incidentally, is author of the NEF study An Environmental War Economy: The lessons of ecological debt and global warming, which uses Britain's World War II "war socialism" as a model for a "sustainable" global economy.
"For years, customers have asked for a .22 rimfire version of our break-action Handi-Rifle," said Robin Sharpless, NEF senior vice president.
All applications and approvals for this programme are managed by the NEF.
President Muhammadu Buhari told Fulani herders In the Southern parts of the country not to obey the quit order issued to them by the Northern Elders Forum (NEF).
Ten students of various departments under the Faculty of Biological Sciences and the Faculty of Earth and Environmental Sciences of Dhaka University (DU) have been awarded "Nagao Natural Environment Foundation (NEF) of Japan scholarship" for their outstanding academic results, reports BSS.