neddylation


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neddylation

A molecular process in which a ubiquitin-like protein, neural precursor cell expressed, developmentally downregulated 8 (NEDD8) is conjugated to proteins, targeting them for roles in cell growth and development.
Molecular pathology Neddylation is linked to Alzheimer's disease, driving the reentry of neurons into the cell cycle, resulting in apoptosis.

neddylation

(ned″ĭ-lā′shŏn)
The binding of NEDD8 to proteins.
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Source:RefSeq mRNA;Acc:NM_213801] ENSSSCG00000009425 laccase (multicopper oxidoreductase) domain containing 1 [Source:HGNC Symbol;Acc:26789] ENSSSCG00000009540 ligase IV, DNA, ATP-dependent [Source:HGNC Symbol;Acc:6601] ENSSSCG00000026536 DCN1, defective in cullin neddylation 1, domain containing 2 [Source:HGNC Symbol;Acc:20328] ENSSSCG00000017142 BAI1-associated protein 2 [Source:HGNC Symbol;Acc:947] ENSSSCG00000017146 ring finger protein 213 [Source:HGNC Symbol;Acc:14539] ENSSSCG00000017169 SEC14-like 1 (S.
The remarkable pleiotropy of CSN is partially explained through its enzymatic activity towards Cullin-RING E3 ubiquitin ligases (CRLs), which are activated by neddylation and inactivated by CSN-mediated deneddylation.
Expression of this miRNA was shown to promote proliferation by regulation of CAND1 [encoded by cullin-associated and neddylation dissociated 1 (CAM51)] (49).