necrotizing

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Related to Necrotizing Hepatopancreatitis: necrotizing fasciitis

necrotizing

 [nek´ro-tīz″ing]
causing necrosis.
necrotizing enterocolitis (NEC) the development of necrotic patches in the intestine that interfere with digestion and absorption and can lead to a paralytic ileus, perforation, and peritonitis. The entire bowel may be affected, or the ischemic necrosis may be localized.

NEC is a serious condition that occurs most often in preterm and very immature neonates; it develops in about 5 per cent of all neonates in neonatal intensive care units. The exact cause of the condition is not known, but it is related to ischemia or poor perfusion of blood vessels in sections of the bowel. The ischemia is thought to occur when an earlier oxygen depletion in the heart and brain, as in anoxia or shock, causes blood to be shunted away from less vital organs such as the intestine.

Since the incidence of NEC is low in neonates who are breast-fed, it is likely that the necrotizing process is initiated by a response to the protein in cow's milk and the profuse multiplication of bacteria that thrive more readily in cow's milk than in breast milk. The gas-forming bacteria invade the damaged intestinal cells, causing them to rupture and producing pneumatosis intestinalis, that is, the presence of air in the submucosal or subserosal surfaces of the colon.

Abdominal x-rays will show a characteristic invasion of air in the intestinal wall. If perforation has occurred, the x-ray will reveal free air in the abdominal cavity. Nonspecific symptoms of NEC usually appear in the first week of life and may be overlooked when caregivers are preoccupied with more obvious life-threatening problems. Typically, the neonate exhibits lethargy, vomiting, distended abdomen, signs of intestinal bleeding, and absence of bowel sounds.

Once the condition is diagnosed, all oral feedings are stopped to rest the intestinal tract. Feeding must then be accomplished intravenously. Gastrointestinal decompression via nasogastric suction may be instituted to relieve distention, and antibiotics administered to limit secondary bacterial infection. Progressive deterioration or evidence of perforation are indications for surgery to remove the diseased portion of the bowel. If damage is extensive an ileostomy or colostomy may be necessary.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

nec·ro·tiz·ing

(nek'rō-tīz-ing)
That which causes the death of tissues or organisms.
See: necrosis
[G. nekros, dead body]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

Necrotizing

Causing the death of a specific area of tissue. Human bites frequently cause necrotizing infections.
Mentioned in: Human Bite Infections
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.

Patient discussion about necrotizing

Q. can necrosis in a brain tumor kill you? If so, how? husband has glioblastoma.Tumor seems under control at this point as much as they can tell but sounds like there is a lot of necrosis. He has lots of tumor progression symptoms but since he has had the tumor for so long == 6 years = I guess the necrosis is there moreso than the actual tumor == how dangerous can this be?

A. Tumors and not only in the brain tend to develop necrosis the longer they exist because the tumor cells divide so rapidly so the blood supply can't keep up with its' own cells demands, so some cells within the tumor die (therefore are seen as necrotic). This does not usually predict prognosis, but only means that the tumor is longstanding.

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References in periodicals archive ?
Detection of the etiologic agent of necrotizing hepatopancreatitis in cultured Penaeus vannamei from Texas and Peru by polymerase chain reaction.
First record of necrotizing hepatopancreatitis bacterium (NHP-B) associated with the zooplankton samples from the Gulf of California, Mexico.
Gene expression responses of white shrimp (Litopenaeus vannamei) infected with necrotizing hepatopancreatitis bacterium.
Physiological and immune responses of white shrimp (Litopenaeus vannamei) infected with necrotizing hepatopancreatitis bacterium.
Three of the groups were infected with necrotizing hepatopancreatitis bacterium (NHP-B) by forced feeding with 40 [micro]L of a homogenate of hepatopancreas (1:1 w/v, hepatopancreas:glycerol) from shrimp confirmed as PCR positive to NHP-B (homogenate was confirmed as free of other pathogens as well).
Necrotizing hepatopancreatitis, a newly described disease syndrome in lobsters, was observed in 15% of the lobsters from Rhode Island.
KEY WORDS: necrotizing hepatopancreatitis, idiopathic blindness, contaminants, epizootic shell disease, histology, American lobster, Homarus americanus
A new disease syndrome, necrotizing hepatopancreatitis, was observed in animals from Rhode Island; therefore, a secondary objective was to describe the pathology of this syndrome and analyze its prevalence in relation to ESD and other conditions.
Molecular phylogeny and in situ detection of the etiologic agent of necrotizing hepatopancreatitis in shrimp.

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