SOCS7(redirected from Nck-Ash and phospholipase C gamma-binding protein)
SOCS7A gene on chromosome 17q12 that encodes a protein that regulates signalling cascades protein ubiquitination and/or sequestration. SOCS7 is involved in insulin signalling and glucose homeostasis through insulin receptor substrate 1 (IRS1) ubiquitination, followed by proteasomal degradation. It also inhibits prolactin, growth hormone and leptin signalling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their DNA binding.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.