NCK1

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NCK1

A gene on chromosome 3q21 that encodes an adapter protein which associates with tyrosine-phosphorylated growth factor receptors (e.g., KDR and PDGFRB) or their substrates. NCK1 maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. It plays a role in DNA damage response by activating downstream effectors, such as that of CHEK2, and in ELK1-dependent
transcriptional activation in response to activated Ras signalling.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Tricoci University is NCK Capital's second investment in the post-secondary education industry.
SOCS7 was first identified through its ability to interact with the SH3 domain of the adaptor protein Nck and is unique in its possession of a proline-rich N-terminal domain and nuclear localisation motif [27].
NCK2, a member of NCK family of adaptor proteins, is reported to be associated with tyrosine-phosphorylated growth factor receptors of their cellular substrate [54].
This study analyzed de-identified nursing data from the KHWIS, an information system developed through a collaboration between the Kenya Department of Nursing (DON), the Nursing Council of Kenya (NCK), the Centers for Disease Control and Prevention (CDC), and the Lillian Carter Center for International Nursing at Emory University, Atlanta, GA, USA.
Phosphorylated IRS proteins act as docking sites for several intracellular proteins such as Grb2, NcK and the regulatory subunit p85 of phosphatidylinositol 3-Kinase (PI3K), which mediate different actions of insulin.
SUN-SHINE DAY: Wallsend New Rising Sun celebrate (above) after beating The Wheatsheaf at Benfield to lift the North East Sunday League's Nck Porter Cup and (left) skipper Steven Whittle lifts the trophy PICTURES: STEVE MILLER
The 0.72-acre development was acquired for $460,000 in December 2006 from NCK LLC, led by Linda Koubek.
Working as a doctor at the Cesky Krumlov hospital (NCK), Mr Vorel contested the way remuneration for standby time was calculated.
ROTA NCK plus precision power chucks feature large through holes, improved lubrication systems, high clamping repeatability, and compatibility with a range of existing machining centers.
Nck Barmby (hamstring) remains sidelined but defender Andy Dawson is available.
He and Mick, who run NCK Property Services, did nothing to their new aquisition for a few months until they felt they'd formed the right idea about how to do it up.