SCN10A

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SCN10A

A gene on chromosome 3p22.2 that encodes a voltage-gated sodium ion channel, which is an integral membrane glycoprotein. It is responsible for the initial rising phase of the action potential in most excitable cells.
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Vertex Pharmaceuticals announced positive results of a Phase 2 study of the NaV1.
By use of a patch clamp, we evaluated the effects of menthol application on tetrodotoxin (TTX)-resistant Nav1.
16] Similar results were obtained in another study performed in relation to the Nav1.
Point mutations in homology domain II modify the sensitivity of rat Nav1.
Other studies of postmortem tissue from injured human nerves and chronic neurogenic pain report significant changes in the level and tissue distribution of Nav1.