SCN9A

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SCN9A

A gene on chromosome 2q24 that encodes an alpha subunit of the voltage-gated sodium channel, which mediates voltage-dependent sodium ion permeability of excitable membranes. The SCN9A protein product plays a major role in nociception signalling.

Molecular pathology
SCN9A mutations are associated with primary erythromelalgia, channelopathy-associated insensitivity to pain and paroxysmal extreme pain disorder.
References in periodicals archive ?
These genes contain the blueprint for the ion channels TRPA1 and NaV1.7. It is already known that these two channels are involved in the perception of pain.
Similar questions are at hand for the Nav1.7 inhibitor that Biogen had taken over from Convergence Pharmaceuticals.
Nav1.7 sodium channel-induced Ca2+ influx decreases tau phosphorylation via glycogen synthase kinase-3beta in adrenal chromaffin cells.
Scientists have discovered that the gene affects sodium channel NaV1.7, which sends pain signals to peripheral nerve cells.
Last summer, Teva and Xenon announced that a compound called TV-45070 that targets NaV1.7 didn't meet mid-stage clinical trial goals for chronic pain conditions.
Two types of VGSCs, Nav1.7 and Nav1.8, are known to contribute to pain transduction in nociceptive neurons [21, 22].
A new study has just revealed that the antinociceptive effects of BTX-A are conferred by inhibiting Nav1.7 upregulation in the trigeminal ganglion [24].
Since nerve damage from diabetic hyperglycemia causes pain, several existing and potential pain drugs and Chromocell novel NaV1.7 blocker compound were evaluated as pain treatments in the subject animals.
Furthermore, the expression levels of the nociceptive channels Nav1.7 and Nav1.8 increased in chronic pain in mice (Figures 2(c) and 2(d), 135.86 [+ or -] 12.99% and 139.16 [+ or -] 16.03%, n = 8), which were reduced by EA and TRPV1 deletions but not in the sham treated group (Figures 2(c) and 2(d), n = 8).
Zhong, "The role of TNF-a/NF-xB pathway on the up-regulation of voltage-gated sodium channel Nav1.7 in DRG neurons of rats with diabetic neuropathy," Neurochemistry International, vol.
Su et al., "Electroacupuncture reduces carrageenan- and CFA-induced inflammatory pain accompanied by changing the expression of Nav1.7 and Nav1.8, rather than Nav1.9, in mice dorsal root ganglia," Evidence-Based Complementary and Alternative Medicine, vol.
The aim of the partnership is to accelerate Purdue's Nav1.7 sodium ion channel drug candidates using AnaBios' Phase-X discovery platform to develop treatments for chronic pain.