SCN4A

(redirected from Nav1.4)
Also found in: Wikipedia.

SCN4A

A gene on chromosome 17q23.3 that encodes an alpha subunit of a transmembrane glycoprotein complex, which forms a voltage-gated sodium channel. The SCN4A protein product is expressed in skeletal muscle.

Molecular pathology
SCN4A mutations are linked to various myotonic and periodic paralysis disorders.
References in periodicals archive ?
The Nav1.4 voltage-gated sodium channel encoded by SCN4A is a transmembrane complex that consists of an a subunit associated with an auxiliary [sz] subunit in the muscle.
Defective polysialylation and sialylation induce opposite effects on gating of the skeletal Na+ channel NaV1.4 in Chinese hamster ovary cells.
In familial Hypokalemic periodic paralysis paradoxical depolarization is caused by mutations in the voltage sensor of Nav1.4 and Cav1.1 channels giving imbalance between inward leak current and outward K current.
Distinct site regulating grayanotoxin binding and unbinding to D4S6 of Nav1.4 sodium channel as revealed by improved estimation of toxin sensitivity.
A phenylalanine residue at segment D3-S6 in Nav1.4 voltage-gated [Na.sup.+] channels is critical for pyrethroid action.