SCN3A

(redirected from Nav1.3)

SCN3A

A gene on chromosome 2q24 that encodes an alpha subunit of a  transmembrane glycoprotein complex, which forms a voltage-gated sodium channel. The SCN3A protein product is expressed in skeletal muscle and neurones.
References in periodicals archive ?
Moreover, intrathecal miR-96 inhibits Nav1.3 expression and alleviates neuropathic pain in rat following peripheral nerve injury (21).
Waxman, "Changes in electrophysiological properties and sodium channel Nav1.3 expression in thalamic neurons after spinal cord injury," Brain, vol.
Waxman, "Upregulation of sodium channel Nav1.3 and functional involvement in neuronal hyperexcitability associated with central neuropathic pain after spinal cord injury," Journal of Neuroscience, vol.
Wu, "Electro-acupuncture-modulated miR-214 prevents neuronal apoptosis by targeting Bax and inhibits sodium channel Nav1.3 expression in rats after spinal cord injury," Biomedicine & Pharmacotherapy, vol.
Hyperexcited ectopic impulses are generated by the expression of various voltage-gated sodium channels, such as Nav1.3, Nav1.7, and Nav1.8 [20].
They showed that painful neuromas (tangled masses of nerves that develop after an amputation or trauma) surgically removed from patients with intractable pain after nerve injury and traumatic limb amputation show accumulation of Nav1.3, Nav1.7 and Nav1.8.
Studies of painful neuromas (tangled masses of nerves that develop as a result of amputation or trauma) surgically removed from patients with intractable pain after nerve injury and traumatic limb amputation show accumulation of Nav1.3, Nav1.7, and Nav1.8 (Black, J.A., et al., 2008).
Alterations in burst firing of thalamic VPL neurons and reversal by Nav1.3 antisense after spinal cord injury.