According to the National Surgical Adjuvant Breast Project (NSABP) B17 protocol, 80% of DCIS cases were nonpalpable (13).
 Nonstandard abbreviations: DCIS, ductal carcinoma in situ; NSABP, National Surgical Adjuvant Breast Project; ER, estrogen receptor; PgR, progesterone receptor; HER2, human epidermal growth factor receptor homolog 2; XRT, radiation; BCS, breast-conserving surgery; CNA, copy number alteration; IHC, immunohistochemistry; COX-2, cyclooxygenase 2; FISH, fluorescence in situ hybridization.
The randomized trials, National Surgical Adjuvant Breast Project protocol B17 (NSABP B17) (24) and the European Organization for Research and Treatment of Cancer 10853 protocol (EORTC 10853)25 have identified the risk of recurrent DCIS as 1% to 2% per year in patients with negative margins, low- to intermediate-grade DCIS, and no adjuvant XRT, whereas in this current series, recurrent PLCIS was also identified at a similar rate, suggesting that the risk for recurrent PLCIS is at least similar to low- to intermediate-grade DCIS.
Pathologic findings from the National Surgical Adjuvant Breast Project (NSABP) Protocol B-17.
Calls were made to the press offices at the National Cancer Institute and the National Surgical Adjuvant Breast Project
to obtain a response to Dr.
The National Cancer Institute in Bethesda, Md., and the American Cancer Society in New York supported these National Surgical Adjuvant Breast Project
Pathologic findings from the National Surgical Adjuvant Breast Project
protocol B-06: 10-year pathologic and clinical prognostic discriminants.