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a polyene antibiotic used in topical treatment of fungal keratitis, blepharitis, and conjunctivitis.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.


An antifungal antibiotic for topical use, produced by Streptomyces natalensis; effective against Aspergillus, Candida, and Mucor species.
Synonym(s): natamycin
Farlex Partner Medical Dictionary © Farlex 2012

antifungal agent 

Any substance which destroys or prevents the growth of fungi. It is one of the antibiotic groups. There are several classes of antifungal drugs: Polyenes, which cause an increase in fungal cell wall permeability leading to its death. Examples: amphotericin B, natamycin, nystatin. Azoles, which act either by inhibiting the synthesis of ergosterol, a component of fungal cell wall or by causing direct wall damage. Examples: clotrimazole, econazole, fluconazole, itraconazole, ketoconazole, miconazole. Pyrimidines, which interfere with the normal function of fungal cells. Example: flucytosine. Syn antimycotic agent.
Millodot: Dictionary of Optometry and Visual Science, 7th edition. © 2009 Butterworth-Heinemann
References in periodicals archive ?
fungal isolates showed high susceptibility as Aspergillus spp isolates were sensitive to Itraconazole (98%), Voriconazole then Amphotericin B and Natamycin (95%,93%,92%) respectively, Pencillium spp.
Natamycin has been considered as a GRAS (generally recognized as safe) product by the FDA (Koontz et al., 2003; Cong et al., 2007) and also registered as a natural preservative by the European Union (EECN235) (Balaguer et al., 2014).
Natamycin, the only commercially available antifungal agent for ophthalmic use, has poor corneal penetration and precipitates on the corneal surface.
Moreover, it was found that patients who received one hourly natamycin eye drops during day and night showed more improvement clinically than those who received one hourly natamycin eye drops only during day time.
The use of benzoate, sorbate, and natamycin in dairy products as additives is forbidden in Iran; only sorbate is permitted for additives in processed cheeses at a maximum level of 1000 mg/kg.
Following the shelf life study, the scientists validated the citric-acetic acid system for storage at 5 C with 20 ppm natamycin, 1000 ppm potassium sorbate, 1000 ppm sodium benzoate, and no antimicrobials at pH 4.6 and 4.2.
Following the show, Khoury removed Natamycin and the case has been closed by LIBNOR, but the expose had a negative impact on the dairy's sales, dropping by 60 or 70 percent.
Antibiotics, natamycin, Vanderzant vitamin mixture, ascorbic acid and yeast were added when the mixture had cooled to 55[degrees]C, and were blended in the beaker.
But he maintained, according to international standards set by the FDA and the World Health Organization, that natamycin was routinely used in products all over the world.
In February, the company pledged to remove artificial preservatives from its most popular varieties of Singles cheese slices by replacing sorbic acid with natamycin. This naturally occurring anti-fungal agent, produced by bacteria during fermentation, is commonly found in soil.
Two culture negative patients were given natamycin and amphotericin, respectively, as fungal keratitis was suspected.
Stiles, "In vitro fungistatic and fungicidal activities of silver sulfadiazine and natamycin on pathogenic fungi isolated from horses with keratomysis," American Journal of Veterinary Research, vol.