Nasonex


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mometasone (nasal)

(moe-met-a-sone) ,

Nasonex

(trade name)

Classification

Therapeutic: anti inflammatories steroidal
Pharmacologic: corticosteroids
Pregnancy Category: C

Indications

Treatment of nasal symptoms of seasonal and perennial allergic rhinitis.Prophylaxis of nasal symptoms of seasonal allergic rhinitis.Treatment of nasal polyps.

Action

Potent, locally acting anti-inflammatory and immune modifier.

Therapeutic effects

Decrease in symptoms of allergic rhinitis and nasal polyps.

Pharmacokinetics

Absorption: Negligible absorption; action is primarily local following nasal use.
Distribution: Crosses the placenta and enters breast milk in small amounts.
Metabolism and Excretion: Rapidly and extensively metabolized by the liver; primarily excreted in bile.
Half-life: 5.8 hr.

Time/action profile (improvement in symptoms)

ROUTEONSETPEAKDURATION
Intranasal within 2 days 1–2 wk unknown

Contraindications/Precautions

Contraindicated in: Hypersensitivity to mometasone.
Use Cautiously in: Active untreated infections; Diabetes or glaucoma; Underlying immunosuppression (resulting from disease or concurrent therapy); Systemic glucocorticoid therapy (should not be abruptly discontinued when intranasal therapy is started); Recent nasal trauma, septal ulcers, or surgery (wound healing may be impaired by nasal corticosteroids); Obstetric / Lactation / Pediatric: Pregnancy, lactation, or children <2 yr (safety not established; prolonged or high-dose therapy may lead to complications).

Adverse Reactions/Side Effects

Central nervous system

  • headache (most frequent)

Ear, Eye, Nose, Throat

  • pharyngitis (most frequent)
  • epistaxis
  • nasal burning
  • nasal irritation
  • nasopharyngeal fungal infection
  • sinusitis

Gastrointestinal

  • vomiting

Genitourinary

  • dysmenorrhea

Endocrinologic

  • adrenal suppression (↑ dose, long-term therapy only)
  • ↓ growth (children)

Musculoskeletal

  • pain

Respiratory

  • cough

Interactions

Drug-Drug interaction

None known.

Route/Dosage

Treatment of Season and Perennial Allergic Rhinitis

Intranasal (Adults and Children ≥12 yr) 2 sprays in each nostril once daily (not to exceed 2 sprays in each nostril once daily).
Intranasal (Children 2–11 yr) 1 spray in each nostril once daily.

Prophylaxis of Seasonal Allergic Rhinitis

Intranasal (Adults and Children ≥12 yr) 2 sprays in each nostril once daily initiated 2–4 wk prior to beginning of pollen season.

Treatment of Nasal Polyps

Intranasal (Adults ≥18 yr) 2 sprays in each nostril 1–2 times daily (not to exceed 2 sprays in each nostril twice daily).

Availability

Nasal spray: 50 mcg/metered spray in 17-g bottle (delivers 120 sprays)

Nursing implications

Nursing assessment

  • Monitor degree of nasal stuffiness, amount and color of nasal discharge, and frequency of sneezing.
    • Patients on long-term therapy should have periodic otolaryngologic examinations to monitor nasal mucosa and passages for infection or ulceration.
    • Monitor growth rate in children receiving chronic therapy; use lowest possible dose.
  • Lab Test Considerations: Periodic adrenal function tests may be ordered to assess degree of hypothalamic-pituitary-adrenal (HPA) axis suppression in chronic therapy. Children and patients using higher than recommended doses are at highest risk for HPA suppression.

Potential Nursing Diagnoses

Ineffective airway clearance (Indications)
Risk for infection (Side Effects)
Deficient knowledge, related to medication regimen (Patient/Family Teaching)

Implementation

  • After the desired clinical effect has been obtained, attempts should be made to decrease dose to lowest amount. Gradually decrease dose every 2–4 wk as long as desired effect is maintained. If symptoms return, dose may briefly return to starting dose.
  • Intranasal: Patients also using a nasal decongestant should be given decongestant 5–15 min before glucocorticoid nasal spray.

Patient/Family Teaching

  • Advise patient to take medication exactly as directed. If a dose is missed, take as soon as remembered unless almost time for next dose.
  • Instruct patient in correct technique for administering nasal spray (see ). Shake well before use. Before first-time use, prime unit by spraying 10 times or until fine spray appears. If not used for at least 7 days, reprime by spraying 2 times or until fine spray appears. Prior to administering dose, gently blow nose to clear nostrils. Close 1 nostril. Tilt head forward slightly and insert nasal applicator into other nostril. Spray and breathe inward through nostril. Breathe out through mouth. Repeat procedure in other nostril. Warn patient that temporary nasal stinging may occur.
  • Instruct patient to notify health care professional if symptoms do not improve within 2 wk, or if symptoms worsen.

Evaluation/Desired Outcomes

  • Resolution or prevention of nasal stuffiness, discharge, and sneezing in seasonal or perennial allergic rhinitis or nasal polyps.
Drug Guide, © 2015 Farlex and Partners

Nasonex

(nā′zə-nĕks′)
A trademark for a preparation of the drug mometasone furoate.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
References in periodicals archive ?
Healthcare company Perrigo Company plc (NYSE:PRGO) (TASE:PRGO) reported on Wednesday the launch of a licensing agreement in the US for Nasonex (mometasone furoate monohydrate) Nasal Spray under Rx-To-OTC Switch strategy with a subsidiary of Merck & Co Inc.
Those include asthma and allergy pill Singulair, allergy spray Nasonex and blood pressure drugs Cozaar and Hyzaar.
"If that does not work, along with the pills, we prescribe a nasal spray containing cortisone, such as Nasonex."
These wet corticosteroid nasal sprays include mometasone (Nasonex), triamcinolone (Nasacort AQ), fluticasone (Flonase), budesonide (Rhinocort) and ciclesonide (Omnaris).
Hidden under the layers of clothes and shoes in my suitcase were my weapons--Claritin, Zyrtec, Allegra, Singulair, Nasonex, Benadryl, Sudafed, Tylenol Sinus, and many more.
2011 Lipitor Pfizer 11.8 Yes 2011 Zyprexa Lilly 4.9 Yes 2012 Enbrel Pfizer 7.4 Yes (received patent extension USA) 2012 Actos Takeda 4.5 Yes 2012 Singulair MSD 4.9 Yes 2012 Diovan Novartis 6.1 Yes 2012 Lexapro Forest 2.8 Yes 2013 Cymbalta Lilly 5.0 No evidence 2013 Niaspan Abbott 1.2 No evidence 2014 Nasonex MSD 1.3 No evidence 2014 Actonel W.C.
For the treatment of allergic rhinitis, nasal corticosteroids that act locally are desirable They include Flonase, Veramyst, Nasonex, Nasacort, and Rhinocort.
Another common prescription is an inhaled steroid such as Nasonex (mometasone) or Beconase (beclomethasone), which will prevent your symptoms and head off inflammation.
These are beclomethasone dipropionate (Beclate), budesonide (Rhino-cort, Budeflam), triamcinolone (Nasacor), fluticasone dipropionate (Flixonase, Flo-mist), mometasone (Nasonex) and fluticasone furoate (Avamys).
From the drugs using for treatment of allergic rhinitis 12 were attributed to group V; among them glucocorticoid means such as "Nasonex", "Nasobek", "Flutinex".
In the merger, Merck acquired popular Schering-Plough brands like the nasal spray Nasonex, the allergy drug Claritin and the Coppertone sunscreen brand.
240 mg, metoprolol succinate 200 mg, spironolactone 50 mg, Glumetza 500 mg, isometheptene-APAP- dichloral, Nasonex 50 mg, Albuterol, Allegra, Ambien, Neu- rontin, Ritalin.