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trademark for a preparation of fenoprofen calcium, a nonsteroidal antiinflammatory drug.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.


(fen-oh-proe-fen) ,


(trade name)


Therapeutic: nonopioid analgesics
Pharmacologic: propionic acid derivatives
Pregnancy Category: C (first and second trimester)
Pregnancy Category: D (third trimester)


Rheumatoid arthritis.Osteoarthritis.Mild to moderate pain.


Inhibits prostaglandin synthesis.

Therapeutic effects

Suppression of pain and inflammation.


Absorption: Well absorbed from the GI tract.
Distribution: Enters breast milk in low concentrations.
Protein Binding: >99%.
Metabolism and Excretion: Mostly metabolized by the liver. 2–5% excreted unchanged by the kidneys.
Half-life: 3 hr.

Time/action profile

PO (analgesic activity)15–30 min1–2 hr4–6 hr
PO (anti-inflammatory activity)several days2–3 wkunknown


Contraindicated in: Hypersensitivity to fenoprofen, aspirin, or other NSAIDS; Active GI bleeding or ulcer disease; Severe renal dysfunction; Perioperative pain in setting of coronary artery bypass surgery.
Use Cautiously in: Cardiovascular, renal, or hepatic disease; History of ulcer disease; Obstetric: Not recommended for use during third trimester; Geriatric: ↑ risk of adverse events; Lactation / Pediatric: Safety not established.

Adverse Reactions/Side Effects

Central nervous system

  • confusion
  • dizziness
  • drowsiness
  • headache

Ear, Eye, Nose, Throat

  • blurred vision
  • hearing loss
  • tinnitus


  • edema
  • palpitations


  • GI bleeding (life-threatening)
  • hepatitis (life-threatening)
  • dyspepsia (most frequent)
  • abdominal pain
  • constipation
  • diarrhea
  • discomfort
  • nausea
  • vomiting


  • cystitis
  • dysuria
  • hematuria
  • renal failure


  • pruritis
  • rashes
  • sweating


  • prolonged bleeding time


  • tremor


  • allergic reactions including anaphylaxis (life-threatening)


Drug-Drug interaction

Concurrent use with aspirin or antacids may ↓ effectiveness.Additive adverse GI effects with aspirin, other NSAIDs, potassium supplements, corticosteroids, or alcohol.May ↓ the effectiveness of diuretics or antihypertensives.May ↑ serum lithium levels and ↑ the risk of toxicity.↑ the risk of toxicity from methotrexate.↑ risk of bleeding with cefotetan, heparin, thrombolytic agents, antiplatelet agents, or warfarin.↑ risk of adverse hematologic reactions with antineoplastics or radiation therapy.Phenobarbital may ↑ metabolism and ↓ effectiveness of fenoprofen.May ↑ the risk of nephrotoxicity withcyclosporine.↑ bleeding risk with anise, arnica, chamomile, clove, feverfew, garlic, ginger, ginkgo, Panax ginseng, and others.


Rheumatoid Arthritis/Osteoarthritis
Oral (Adults) 400–600 mg 3–4 times daily (not to exceed 3.2 g/day).
Mild-to-Moderate Pain
Oral (Adults) 200 mg q 4–6 hr.

Availability (generic available)

Capsules: 200 mg, 400 mg
Tablets: 600 mg

Nursing implications

Nursing assessment

  • Patients who have asthma, aspirin-induced allergy, and nasal polyps are at increased risk for developing hypersensitivity reactions. Monitor for rhinitis, asthma, and urticaria.
  • Arthritis: Assess pain and range of movement before and 1–2 hr after administration.
  • Pain: Assess pain (type, location, and intensity) before and 1–2 hr after administration.
  • Lab Test Considerations: May cause prolonged bleeding time.
    • May cause ↓ hemoglobin, hematocrit, leukocyte, and platelet counts.
    • Monitor liver function tests periodically during long-term therapy. May cause ↑ serum alkaline phosphatase, LDH, AST, and ALT concentrations.
    • Monitor BUN, serum creatinine, and electrolytes periodically during therapy. May cause ↑ BUN and serum creatinine.

Potential Nursing Diagnoses

Acute pain (Indications)
Impaired physical mobility (Indications)
Deficient knowledge, related to medication regimen (Patient/Family Teaching)


  • Administration in higher than recommended doses does not provide increased effectiveness but may cause increased side effects.
    • Coadministration with opioid analgesics may have additive analgesic effects and may permit lower opioid doses.
  • Oral: For rapid initial effect, administer 30 min before or 2 hr after meals. Administer after meals or with food to minimize gastric irritation.

Patient/Family Teaching

  • Advise patient to take this medication with a full glass of water and to remain in an upright position for 15–30 min after administration.
  • Instruct patient to take medication as directed. Take missed doses as soon as remembered, but not if almost time for next dose. Do not double doses.
  • May cause drowsiness or dizziness. Advise patient to avoid driving or other activities requiring alertness until response to the medication is known.
  • Caution patient to avoid concurrent use of alcohol, aspirin, acetaminophen, other NSAIDs, or other OTC or herbal products without consulting health care professional.
  • Instruct patient to notify health care professional of medication regimen before treatment or surgery.
  • Advise patient to consult health care professional if rash, itching, visual disturbances, tinnitus, weight gain, edema, black stools, persistent headache, or influenza-like syndrome (chills, fever, muscle aches, pain) occurs.

Evaluation/Desired Outcomes

  • Decrease in severity of pain.
  • Improved joint mobility. Partial arthritic relief is usually seen within a few days, but maximum effects may require 2–3 wk of continuous therapy. Patients who do not respond to one NSAID may respond to another.
Drug Guide, © 2015 Farlex and Partners


Fenoprofen, see there.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.