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(naff-ti-feen) ,


(trade name)


Therapeutic: antifungals
Pregnancy Category: B


Treatment of a variety of cutaneous fungal infections, including tinea pedis (athlete’s foot), tinea cruris (jock itch), and tinea corporis (ringworm).


Affects the synthesis of the fungal cell wall.

Therapeutic effects

Decrease in symptoms of fungal infection.


Absorption: Absorption through intact skin is minimal.
Distribution: Distribution after topical administration is primarily local.
Metabolism and Excretion: Systemic metabolism and excretion not known following local application.
Half-life: Not applicable.

Time/action profile



Contraindicated in: Hypersensitivity to active ingredients, additives, preservatives, or bases; Contains alcohol and should be avoided in patients with known intolerance.
Use Cautiously in: Nail and scalp infections (may require additional systemic therapy); Obstetric / Lactation: Safety not established.

Adverse Reactions/Side Effects


  • burning
  • dryness
  • itching
  • local hypersensitivity reactions
  • redness
  • stinging


Drug-Drug interaction

Not known.


Topical (Adults) Apply cream once daily for 2 wk. Apply gel twice daily for up to 4 wk.


Cream: 2%
Gel: 1%

Nursing implications

Nursing assessment

  • Inspect involved areas of skin and mucous membranes before and frequently during therapy. Increased skin irritation may indicate need to discontinue medication.

Potential Nursing Diagnoses

Risk for impaired skin integrity (Indications)
Risk for infection (Indications)


  • Consult health care professional for proper cleansing technique before applying medication.
  • Topical: Apply small amount to cover affected area completely. Avoid the use of occlusive wrappings or dressings unless directed by health care professional.

Patient/Family Teaching

  • Instruct patient to apply medication as directed for full course of therapy, even if feeling better. Emphasize the importance of avoiding the eyes and vaginal area.
  • Caution patient that some products may stain fabric, skin, or hair. Check label information. Fabrics stained from cream can usually be cleaned by handwashing with soap and warm water.
  • Patients with athlete’s foot should be taught to wear well-fitting, ventilated shoes, to wash affected areas thoroughly, and to change shoes and socks at least once a day.
  • Advise patient to report increased skin irritation or lack of response to therapy to health care professional.

Evaluation/Desired Outcomes

  • Decrease in skin irritation and resolution of infection. Early relief of symptoms may be seen in 2–3 days.
References in periodicals archive ?
A new formulation of naftifine hydrochloride 2% (Naftin), a potent prescription topical allylamine antifungal available as a cream or a gel, has shown equivalent efficacy with just 2 weeks of treatment.
Merz also offers the most frequently prescribed branded Rx topical antifungal treatment, Naftin, which is available as a cream and a gel.
In a 4-week study involving 104 patients, naftifine 1% cream (Naftin) was compared with econazole 1% cream (Spectazole) (both applied twice daily).
Drug Dosage Cost/Tube(*) Ciclopirox twice a day $31.83 (Loprox) clotrimazole twice a day $14.87 econazole once or $31.78 (Spectazole) twice a day ketoconazol once or $31.78 twice a day naftifine twice a day $31.73 (20g) (Naftin) $54.40(40g) terbinafine twice a day $58.40 (Lamisil) SYSTEMIC AGENTS Drug Dosage Cost/Tube(*) Terbinafine 250 mg/day $8.68 (Lamisil) itraconazole 200-400 mg/day $15.56 (200 mg) (Sporanox) TROPICAL AGENTS Drug [dagger]Comment Ciclopirox Pyradone, formulated as cream, gel, lotion, and topical (Loprox) suspension.
Drug Dosage Cost/Tube * ciclopirox twice a day $31.83 (Loprox) clotrimazole twice a day $14.87 econazole once or $28.70 (Spectazole) twice a day ketoconazole once or $31.78 twice a day naftifine twice a day $31.73 (20 (Naftin) g); $54.40 (40 g) terbinafine twice a day $58.40 (Lamisil) SYSTEMIC AGENTS Drug Dosage Cost/Day ** terbinafine 250 mg/day $8.68 (Lamisil) itraconazole 200-400 $15.56 (200 (Sporanox) mg/day mg) Drug Comment ([dagger]) ciclopirox Pyradone, formulated as cream, gel, lotion, and topical (Loprox) suspension.
Merz also offers Naftin, the most frequently prescribed branded topical antifungal treatment.
TABLE RECOMMENDED TOPICAL TREATMENTS FOR TINEA PEDIS Cure Frequency Bates, and duration Drug % Form of treatment * Comments Miconazole 47 2% lotion, BID for 2-4 Inexpensive, (Micatin) spray, weeks OTC cream, powder Terbinafine 70 1% cream, BID for 1-2 Shorter length (Lamisil) solution, weeks of treatment, spray OTC Naftifine 70 1% gel, QD for 2-4 Once a day, Rx (Naftin) cream weeks Butenafine 70 1% cream QD for 4 Once a day, Rx (Mentax) weeks Tolnaftate 64 1% powder, BID for 2-4 Inexpensive, (Tinactin, spray, cream weeks OTC Altate) Rx denotes prescription; OTC, over the counter; BID, twice a day; QD, every day.
Merz expanded into other areas of therapeutic skin care in 1999 with the acquisition of Naftin topical antifungal and Aqua Glycolic, an alpha-hydroxyacid-based line.
"As expected, the podiatrists were very interested in Naftin, the premiere prescription antifungal treatment for tinea that we recently acquired from Allergan Inc.," explains Connell.