RANBP2

(redirected from NUP358)

RANBP2

A gene on chromosome 2q12.3 that encodes a very large RAN-binding protein that immunolocalises to the nuclear pore complex. It is a scaffold and mosaic cyclophilin-related nucleoporin involved in the Ran-GTPase cycle; it interacts directly with the E2 enzyme UBC9 and enhances the transfer of SUMO1 (sumoylation) to its target SP100. RANBP2 is partially duplicated in a gene cluster that lies in the chromosome 2 recombination hot spot.
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Cytoplasmic filaments are predominantly composed of Nup88, Nup214 (CAN), and Nup358 (RanBP2), whereas the main constituents of the nuclear basket are Tpr, Nup153, and Npap60 (Nup50).
On the other hand, although Ran has its own weak hydrolytic activity, the hydrolysis of RanGTP to RanGDP is strongly accelerated by the GTPase-activating protein RanGAP1, in conjunction with Ran binding protein 1 (RanBP1) and/or Ran binding protein 2 (RanBP2, also called Nup358).
A part of the HIV virus called the capsid protein, acting like a key, binds to Nup358, a protein on the nuclear pore complex, unlocking the gateway and granting the virus access to the DNA.