NUDT15

NUDT15

A gene on chromosome 13q14.12 that encodes an enzyme which hydrolyses some nucleoside diphosphate derivatives. Its function in vivo is unknown—it may play a role in DNA synthesis and cell cycle progression by interacting with PCNA. NUDT15 may remove oxidatively damaged guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool, thereby preventing its misincorporation into DNA and A:T to C:G transversions.
References in periodicals archive ?
Researchers reported that patients who inherited either one or two copies of the newly identified variation in the NUDT15 gene were extremely sensitive to the drug mercaptopurine.
In this study, patients of East Asian and Hispanic background were more likely to inherit the NUDT15 variant than those from other racial and ethnic groups.
Patients who inherited variations in TPMT or NUDT15 tolerated mercaptopurine at significantly lower doses than patients who inherited the more common versions of the genes.
Researchers suspect that the NUDT15 variant acts in a similar fashion.