Third, using a candidate-gene approach based on a literature search for air pollution associated genes we investigated separately a set of 739 CpGs in 38 antioxidant and inflammatory genes (TGFB1, ARG1, ARG2, GSTM1, GSTP1, NQO1, SOD2, GPX1, HMOX-1, CAT, GSTT1, EPHX1, NOS2, TNF, NFE2L2, GSS, GPX7, GPX2, GSTZ1, ALB, SRXN1, NOX5, ALOX12, NCF2, AOX1, MPV17, SIRT2, MBL2, OXSR1, OXR1, NUDT1
, DUOX2, EPX, PXDNL, PXDN, MPO, LPO, TPO) (Carlsten and Melen 2012; Chen et al.
miR-145 could regulate the expression of various targets in different tumors: FSCN1 in esophageal squamous cell carcinoma , OCT4, EGFR, and NUDT1 in lung adenocarcinoma [51, 52], and FLI1 in colon cancer .
Au, "MiR-145 inhibits cell proliferation of human lung adenocarcinoma by targeting EGFR and NUDT1," RNA Biology, vol.
Moreover, 8-oxoguanine is removed from DNA by (7),(8)-dihydro-8-oxoguanine-DNA glycosylase (OGG1), whereas the nucleoside diphosphate linked moiety X-type motif 1 (NUDT1) enzyme removes 8-oxo-2'-deoxyguanosine 5'-triphosphate (8-oxo-dGTP) from the nucleotide pool, preventing incorporation of 8-oxoguanine during repair processes or replication (Loft and Mller 2006).
Expression levels of HO-1, OGG1, and NUDT1 mRNA by real-time RT-PCR.