NUDT1

NUDT1

A gene on chromosome 7p22 that encodes an antimutagenic enzyme which prevents misincorporation of 8-oxo-dGTP into DNA, thus blocking A:T to C:G transversions.
References in periodicals archive ?
Third, using a candidate-gene approach based on a literature search for air pollution associated genes we investigated separately a set of 739 CpGs in 38 antioxidant and inflammatory genes (TGFB1, ARG1, ARG2, GSTM1, GSTP1, NQO1, SOD2, GPX1, HMOX-1, CAT, GSTT1, EPHX1, NOS2, TNF, NFE2L2, GSS, GPX7, GPX2, GSTZ1, ALB, SRXN1, NOX5, ALOX12, NCF2, AOX1, MPV17, SIRT2, MBL2, OXSR1, OXR1, NUDT1, DUOX2, EPX, PXDNL, PXDN, MPO, LPO, TPO) (Carlsten and Melen 2012; Chen et al.
Other five genes, DUSP1, EPHX2, NUDT1, RNF7, and SEPP1, demonstrated a statistically significant modulation in poor prognosis patients in three out of six tumor types (Figure 3 and Suppl.
miR-145 could regulate the expression of various targets in different tumors: FSCN1 in esophageal squamous cell carcinoma [50], OCT4, EGFR, and NUDT1 in lung adenocarcinoma [51, 52], and FLI1 in colon cancer [53].
Au, "MiR-145 inhibits cell proliferation of human lung adenocarcinoma by targeting EGFR and NUDT1," RNA Biology, vol.
Moreover, 8-oxoguanine is removed from DNA by (7),(8)-dihydro-8-oxoguanine-DNA glycosylase (OGG1), whereas the nucleoside diphosphate linked moiety X-type motif 1 (NUDT1) enzyme removes 8-oxo-2'-deoxyguanosine 5'-triphosphate (8-oxo-dGTP) from the nucleotide pool, preventing incorporation of 8-oxoguanine during repair processes or replication (Loft and Mller 2006).
Expression levels of HO-1, OGG1, and NUDT1 mRNA by real-time RT-PCR.