NTRK3

NTRK3

A gene on chromosome 15q25 that encodes TrkC receptor, a tyrosine-protein kinase receptor activated by neurotrophin-3 (NT-3) and is found on proprioceptive sensory neurons; its substrates include SHC1, PI-3 kinase and PLCG1.
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Ignyta and the European Organisation for Research and Treatment of Cancer (EORTC) declared that they will partner through EORTCs Screening Patients for Efficient Clinical Trial Access (SPECTA) biomarker screening move to recognize patients who harbor a gene rearrangement to NTRK1, NTRK3, ROS1 or ALK and therefore may be competent for Ignytas global STARTRK-2 Phase 2 clinical study.
In the cooperation between SPECTA and Ignyta, eligible patients showing positive for a gene rearrangement to NTRK1, NTRK3, ROS1 or ALK are to be specially suggested for enrollment in the STARTRK-2 clinical trial.
The landscape of kinase fusions in cancer) suggests NTRK fusion events may drive tumorigenesis in multiple cancers, with a total of 23 NTRK1, NTRK2 and NTRK3 fusions identified across nine tumor types.
On the other hand, the NTRK3 gene is located on chromosome 15 and encodes a membrane receptor tyrosine kinase.
Similar to the namesake tumor in the breast, the salivary gland mammary analogue secretory carcinoma harbors a translocation between the ETV6 and the NTRK3 genes.