NTRK3

NTRK3

A gene on chromosome 15q25 that encodes TrkC receptor, a tyrosine-protein kinase receptor activated by neurotrophin-3 (NT-3) and is found on proprioceptive sensory neurons; its substrates include SHC1, PI-3 kinase and PLCG1.
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According to the company, the Seraseq NTRK FFPE RNA reference material contains 15 clinically significant NTRK RNA fusions across NTRK1, NTRK2 and NTRK3 genes and are to be used by clinical laboratories looking to validate their detection by next-generation sequencing (NGS) methods.
Another set of patients demonstrate translocation involving tyrosine kinases, such as ABL1 (with genes other than BCR), ABL2, PDGFRB, NTRK3, TYK2, CSF1R, and JAK2.
ETV6 is genetically unstable and fuses not only with NTRK3 but also with other genes, including ABL1, EGFR3, PAX5, SYK and JAK2 in leukaemia, myelodysplastic syndromes, and sarcomas (7).
Mousavi Ardehaie et al., "Detection of aberrant methylated SEPT9 and NTRK3 genes in sporadic colorectal cancer patients as a potential diagnostic biomarker," Oncology Letters, vol.
Taguchi et al., "ALK, ROS1 and NTRK3 gene rearrangements in inflammatory myofibroblastic tumours," Histopathology, vol.
ThyroSeq v2 panel Gene mutations Gene fusions Gene expression (RNA) (DNA) (RNA) BRAF RET RET PGK1 Pan-cell NRAS TSHR PPARG KRT7 HRAS AKT1 NTRK1 TG Thyroid cell KRAS TP53 NTRK3 TTF1 PIK3CA GNAS BRAF NIS PTEN CTNNB1 ALK Calcitonin MTC TERT EIF1AX PTH Parathyroid KRT20 Metastatic
identified 5 SC cases with atypical junctions, exon 4 of ETV6 with exon 14 of NTRK3, and exon 5 of ETV6 with exon 14 of NTRK3 that have not been described in SC so far [16].
The patient developed resistance to the drug later in the course of the disease due to the NTRK3 G623R mutation.
Esta enfermedad se puede generar por herencia genetica o por radiacion, y se ven afectados genes como: RET, BRAF, RAS, EIF1AX, PPM1D y CHEK2 y translocaciones que afectan PPARg, NTRK1, NTRK3, THADA y FGFR2, ademas de alteraciones moleculares como cadherina epitelial, molecula neural de adhesion celular (N-CAM), p-catenina, p53 y p63 [1,3].
AKT1 CTNNB1 FGFR1 GNAS KRAS NRAS PIK3R5 STAT1 AKT2 EGFR FGFR2 HRAS MAP2K1 NTRK1 PKHD1 TEC AKT3 ERBB2 FGFR3 IDH1 MAP2K2 NTRK2 PRKCB1 TP53 (HER2) ALK ERCC6 FGFR4 IDH2 MAP2K7 NTRK3 RAF1 BRAF FBX4 FOXL2 IGF1R MET PDGFRA RET CDK4 FBXW7 GNA11 KDR MYC PIK3R1 SMO CSF1R FES GNAQ KIT NEK9 PIK3R4 SOS1
(6) Genomic rearrangement and fusion involving other receptor tyrosine kinases including ROS1, RET, NTRK3, and PDGFRB have been found in IMTs that are negative for ALK rearrangement.