NTRK2


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NTRK2

A gene on chromosome 9q22.1 that encodes neurotrophic tyrosine kinase receptor type 2 (TrkB), which has the highest affinity for brain-derived neurotrophic factor (BDNF) and is involved in neuronal plasticity, long-term potentiation and apoptosis of CNS neurons. TrkB is activated by BDNF, but also by NT-3 and NT-4.
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Expression of NTRK2 also correlates with squamous carcinoma of lung, although less so than NTRK1 (139 of 271 cases positive, Kendall [tau]-b = 0.
Correlation of NTRK1 and NTRK2 Immunohistochemistry and Patient Outcome
There is a significant positive correlation between positive NTRK2 staining in squamous carcinoma and improved DSS (log-rank test, [chi square] = 11.
NTRK2 expression status in adenocarcinoma is not significantly correlated with DSS (log-rank test, [chi square] = 1.
NTRK1 and NTRK2 are preferentially expressed in squamous cell carcinoma of lung when compared with other histologic subtypes of lung carcinoma, most notably adenocarcinoma.
We are presently exploring the utility of NTRK1 and NTRK2 in this manner by comparison with other markers including p63, CK5/6, CK7, and TTF-1.
We found the immunohistochemical expression of NTRK2 to be a significant predictor of improved DSS and OS in squamous cell lung carcinoma.
There are few previous studies of the immunohistochemical expression of NTRK1 and NTRK2 in lung cancer with which to compare our results.
The association of NTRK2 with better patient outcome in squamous cell lung carcinoma suggests an important role for NTRK2 in the biology of this tumor, and it is interesting to speculate about the underlying mechanism.