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Intermediate outcomes, or citation metrics of NTP publications (reports and journal articles), were used as a metric of informing science in stakeholder groups.
A Public Health Service subcommittee is now comparing the NTP findings with other animal and human studies, and will likely issue its recommendations on fluoridation in July.
The NTP selected testicular tumors for evaluation because incidence of the disease is increasing in men in certain regions of the world and the there is concern that current NTP rodent models (F344/N rat and B6C3F1/N mouse) are not optimal for identifying potential human testicular carcinogens (NTP 2005a).
Simulation studies suggest that this isotonic regression-based test performs better than does the NTP trend test when the tumor rates increase nonlinearly in dose (Peddada et al.
NIEHS and NTP scientists increasingly suspected that extant in vitro models were insufficient to understanding the action of nonmutagenic carcinogens: "it was our conviction that in order to understand how nonmutagenic carcinogens cause tumors, we would have to look at whole animals" (Tennant RW, interview with author, 2003).
NTP Software OSCC for StorageGRID is available immediately from NTP Software and its resellers.
The NTP roadmap has identified four key scientific areas as priorities.
Therefore, the NTP is making available the microarray results, individual animal pathology diagnoses, clinical chemistry, hepatic glutathione levels, and individual animal data such as body weights.
NTP Report on carcinogens: history, concepts, procedure, processes.
With strong leadership provided by the Palladian team, NTP has fulfilled its original promise by continuing the company's established path of profitable growth," noted Neil Marks, Managing Partner at Praesidian.
Now 25 years old, the NTP is in the middle of a strategic planning effort to define how it will integrate new technologies with classical toxicological approaches to continue providing, according to the NTP's motto, "good science for good decisions.
Founded in 1992, NTP Incorporated is a privately-held intellectual property firm based in Richmond, Virginia that was founded by the late inventor Thomas Campana, Jr.
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