PCGF1

(redirected from NSPC1)

PCGF1

A gene on chromosome 2p13.1 that encodes a protein that acts as transcriptional repressor to regulate anterior-posterior patterning in early embryonic development.
References in periodicals archive ?
KDM2B is a component of the noncanonical PRC1 (polycomb repressive complex 1), and it recruits Ring1B and Nspc1 to promote H2AK119 monoubiquitylation [53].
For instance, Nspc1, a polycomb protein and a transcriptional repressor that is highly expressed in undifferentiated P19 cells, directly activates the Oct4 promoter [161], which in itself gets negatively regulated following RA treatment [78, 108, 162-165].
Gong, "Nspc1 regulates the key pluripotent Oct4-Nanog-Sox2 axis in P19 embryonal carcinoma cells via directly activating Oct4," Biochemical and Biophysical Research Communications, vol.