NSAID enteropathy

NSAID enteropathy

A general term for small intestinal disease that develops in up to 2/3 of patients receiving long-term NSAIDs, 10% of whom have evidence of small bowel ulceration at autopsy; COX-2 inhibitors are somewhat protective.
 
Clinical findings
Intestinal inflammation; occult blood loss; protein-losing enteropathy; iron deficiency due in part to nonspecific small intestinal ulceration—in particular of the jejunum and ileum—with haemorrhage and perforation, intestinal strictures anoccidia stenoses.

NSAID enteropathy

An enteropathy induced by NSAIDs Clinical Intestinal inflammation, occult blood loss, protein-losing enteropathy, iron-deficiency due in part to nonspecific small intestinal ulceration–in particular of the jejunum and ileum, with hemorrhage and perforation, intestinal strictures, ileal stenoses. See Nonsteroidal anti-inflammatory drug.
References in periodicals archive ?
Until recently, NSAID enteropathy was underappreciated owing to subclinical injury and difficulty in direct evaluation of the small intestine.
We hypothesize that chronic PPI therapy may have both exacerbated NSAID enteropathy by shifting the bacterial flora (eg, reducing Actinobacteria) and promoted survival and germination of Clostridium spores in the gastric environment.